1493. The prevalence and risk factors of HIV-associated neurocognitive disorder in HIV-infected Koreans: Korean NeuroAIDS Project
Session: Poster Abstract Session: Global HIV
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Posters
  • C-1493.pdf (218.6 kB)
  • Background: HIV-associated neurocognitive disorder (HAND) is an independent predictor of early mortality, and strongly predictive of a wide variety of difficulties in activities of daily living. We conducted a study to determine the prevalence and risk factors of HAND in HIV-infected Koreans. In addition, we investigated the performance of screening tools and components of neuropsychological (NP) tests for diagnosing HAND.

    Methods: Two hundred HIV-infected patients were recruited consecutively from two different urban teaching hospitals in Seoul, South Korea between Mar 2012 and Sep 2012. Six subjects were excluded due to confounding comorbidity and withdrawing their agreement. Subjects completed a detailed neuropsychological assessment measuring their functioning in 6 cognitive domains known to be commonly affected by HIV. The Frascati criteria were used for diagnosing HAND. Four key questionnaires, international dementia scale (IDS) and MOCA-K were assessed as a screening tool.

    Results: Among the 194 enrolled participants, the prevalence of HAND was 26.3%. Asymptomatic HAND and mild HAND accounted for 52.9% and 47.1% of the patients with HAND, respectively. In multivariate analysis, hemoglobin levels ≤13g/dL (p=0.046) and current use of PI-based regimen (p=0.031) were independent risk factors for HAND. The area under curves of key questionnaires, IDS and MOCA-K for diagnosing HAND were 0.584 (p=0.051), 0.678 (p<0.001) and 0.666 (p<0.001), respectively. Among NP tests, the Grooved Pegboard Test had the highest sensitivity and modest specificity (90.2% and 72.0%, respectively), and that of Wisconsin Card Sorting Test were 61.2% and 84.4%, respectively.

    Conclusion: The prevalence of HAND in HIV-infected Koreans was similar with those of western countries. IDS and MOKA-K as a screening tool for HAND had insufficiently better performance than key questionnaires. The Grooved Pegboard Test might be used as a screening tool for HAND in HIV infected Koreans.

    Nam Su Ku, MD1, Young-Joon Lee2, Jin Young Ahn, MD1, Je Eun Song, M.D.1, Min Hyung Kim, M.D.1, Sun Bean Kim, MD1, Su Jin Jeong, MD/PhD1, Kyung-Wook Hong, MD3, Eosu Kim2, Sang Hoon Han, MD1, Joon Young Song, MD3, Young Goo Song, MD1, Hee Jin Cheong, MD3, Woo Joo Kim, MD3, June Myung Kim, MD1 and Jun Yong Choi, MD, PhD1, (1)Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea, (2)Department of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea, (3)Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea

    Disclosures:

    N. S. Ku, None

    Y. J. Lee, None

    J. Y. Ahn, None

    J. E. Song, None

    M. H. Kim, None

    S. B. Kim, None

    S. J. Jeong, None

    K. W. Hong, None

    E. Kim, None

    S. H. Han, None

    J. Y. Song, None

    Y. G. Song, None

    H. J. Cheong, None

    W. J. Kim, None

    J. M. Kim, None

    J. Y. Choi, None

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