1310. hypermucoviscosity associated with Klebsiella pneumoniae; Epidemiology and clinical manifestation
Session: Poster Abstract Session: Below the Diaphragm
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
  • No 1310, KimYJ.pdf (714.0 kB)
  • Background: Recently, K.pneumoniae with hypermucoviscous (HV) phenotype is emerging and demonstrates an ability for metastatic spread of infection. In this study, we investigated the incidence, the clinical characteristics and outcomes in patients of K.pneumoniae with HV phenotype in a tertiary hospital of Korea.

    Methods: From January 2011 to June 2012, a total of 1,543 patients who isolated K.pneumonia strains in clinical samples were collected from a 1,200 bed tertiary hospital in Korea. HV phenotype of the K.pneumoniae was determined using a modified string test.

    Results: Among a total of 1,543 patients cultivated with K.pneumoniae, 233 isolates expressed the HV phenotype in 226 patients (14.6%). They were isolated from 154 respiratory tract, 28 abscess, 24 blood, 9 urine, 7 wound, 6 bile, 3 sinus, 1 CSF and 1 peritoneal fluid. ESBL production rate of HV K.pneumoniae was 2.1% (n=5). HV associated K. pneumonia infection was developed in 137 patients (61%), and 89 patients were considered to be colonized. The presence of abscess was detected in 38 patients (17%); 22 liver, 4 perianus, 4 intraabdomen, 2 lung, 2 prostate, 2 head and neck, 1 kidney, and 1 epidural abscess. The metastatic infection to the distant sites occurred in 5.8% (n=8) of infected patients with HV K.pneumoniae and the infection related mortality was 9.5% (13/137).

    Conclusion: Prevalence of HV phenotype of K. pneumonia is high in clinical setting of Korea. Clinicians should be aware of the virulence of HV phenotype in K. pneumonae because of severe clinical characteristics and significant mortality rate, although production of ESBL is extremely low.

    Youn Jeong Kim1, Yoon Hee Jeon1, Sang Il Kim1 and Yang Ree Kim2, (1)The Catholic University of Korea, Seoul, South Korea, (2)The Catholic Univeristy of Korea, Seoul, South Korea


    Y. J. Kim, None

    Y. H. Jeon, None

    S. I. Kim, None

    Y. R. Kim, None

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