1245. Characteristics Associated with Current Hepatitis C Virus Infection in the United States, 2003-2010
Session: Oral Abstract Session: Hot Topics in Public Health
Saturday, October 5, 2013: 10:45 AM
Room: The Moscone Center: 220-226
Background:

HCV antibody (anti-HCV) test alone will not distinguish current from resolved infection, whether spontaneously or by treatment.  Because antiviral therapies are effective means to reduce the number of persons with HCV viremia, the proportion of persons with current infection will decrease among those tested positive for anti-HCV. 

Methods:

We described characteristics associated with current hepatitis C virus, defined by HCV RNA positivity, in adults 40 years of age or older, and the percentage of current HCV infection among those tested positive for anti-HCV. Data were from 4 cycles of National Health and Nutrition Examination Surveys (NHANES), collected from 2003–2010. All analyses were performed using SUDAAN 11.0 to account for the complex survey design.

Results:

Of 31,034 participants, 304 were identified to be positive for anti-HCV. Of these, 238 or 75.4% (95% CI 67.5–81.8) had current HCV infection. The percentages of current HCV infection were highest among non-Hispanic blacks (91.1%) and lowest among those with college or more education (57.3%). This percentage was 92.7% among non-Hispanic blacks and 61.9% among non-Hispanic whites in NHANES 2009-2010. Among persons with current HCV infection, most had elevated ALT (56.5%) or AST (71.8%) levels, but only 35.3% reported having received a diagnosis of “liver condition”.  Excessive alcohol drinking in the past year was reported by 27.3% of participants with current infection.

Conclusion:

Among adults >40 years having ever been infected with HCV, three quarters had current HCV infection. Non-Hispanic blacks were more likely to have current infection.  Among those with current HCV infection, most had abnormal liver function tests and many may benefit from lifestyle modifications, but only a minority appeared to have received appropriate diagnoses.

Fujie Xu, MD, PhD, Epidemiology and Surveillance Branch, Division of Viral Hepatitis, Atlanta, GA, Gui Liu, MPH, Emory University, Atlanta, GA and Scott Holmberg, MD, MPH, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA

Disclosures:

F. Xu, None

G. Liu, None

S. Holmberg, None

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