124. Human metapneumovirus circulation in the US---2007-2013
Session: Oral Abstract Session: Epidemiology of Respiratory Infections
Thursday, October 3, 2013: 11:30 AM
Room: The Moscone Center: 300
Background: Human metapneumovirus (hMPV) occurs in seasonal patterns and has been associated with bronchiolitis and pneumonia in persons of all ages, especially young children.  However, hMPV seasonality in the US has not been well described.

Methods: The National Respiratory and Enteric Virus Surveillance System (NREVSS) passively collects results of specimens tested for respiratory viruses, including hMPV by reverse transcription-polymerase chain reaction (RT-PCR) and antigen (AG) detection methods.  National weekly aggregates of specimens tested and positive results were calculated along with the weekly proportion positive. We limited our analysis to institutions that reported ≥1 hMPV specimen each week for 36 weeks between June and July of each year.  We describe hMPV activity based on season onset, offset and duration. The onset is the first of two consecutive weeks when the weekly proportion positive tests exceeds 5% and the offset is the last of two consecutive weeks when the weekly proportion positive tests exceeds 5%. The duration is the number of weeks inclusive between onset and offset.

Results: We observed 6 distinct hMPV epidemic periods between 2007-2013. NREVSS received 784,403 hMPV test results, 25,483(3.2%) of which tested positive by AG or RT-PCR from July 7, 2007 through April 13, 2013. hMPV onsets ranged from late-December through early-April and lasted until late-March through early-June. The 5% threshold captured 15-78% of specimens positive by antigen or RT-PCR annually from June to July. The duration of each epidemic period ranged from 4-15 weeks each season. From July 4, 2009 until April 13, 2013, 56-78% of hMPV positive specimens were captured by the 5% threshold and the epidemic periods ranged from 13-15 weeks.

Conclusion: hMPV circulation based on laboratory detections begins in winter and lasts until spring. Physicians should consider hMPV as an etiologic agent, especially during epidemic periods.

Amber Haynes, MPH1, Eileen Schneider, MD, MPH2 and Susan Gerber, MD2, (1)National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, (2)Centers for Disease Control and Prevention, Atlanta, GA


A. Haynes, None

E. Schneider, None

S. Gerber, None

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