1058. How do Regional Differences in Antibiotic Consumption Correlate with the Number of Trade Names in a Market?
Session: Poster Abstract Session: Stewardship: Improving Treatments
Friday, October 4, 2013
Room: The Moscone Center: Poster Hall C
  • POSTERPRINCETON[NB].pdf (667.3 kB)
  • Does Antibiotic Consumption Increase with the Number of Trade Names in a Market? A Global Study.

    Carmina A Mancenon 1

    Nikolay P Braykov, BS 2

    Ramanan Laxminarayan, PhD, MPH  1, 2, 3

    (1) Princeton University, Princeton NJ, United States 2) Center for Disease Dynamics, Economics & Policy, Washington, DC, United States (3) Public Health Foundation of India, New Delhi, India

    Background:  Market competition may be a driver of antibiotic use, which in turn decreases antibiotic effectiveness. A 2005 study by Monnet, et al found a positive relationship between consumption and the number of trade names of oral antibacterial agents across five European countries and eight antibacterial classes. We investigate whether this correlation holds a broader scale by including data from lower and middle-income countries.  

    Methods:  Data from 60 countries on the number of brand names and the per-capita volume of oral fluoroquinolones (FQ) and aminopenicillins (AP) sold in retail pharmacies between 01/1999 and 12/2010 came from IMS Health's MIDAS database. FQ and AP were chosen because they include popular brands indicated for the treatment of upper respiratory tract infections. Spearman rank coefficients (r) between consumption (measured in standard units per capita) and the number of brands were calculated, with stratifications for class, region and World Bank income classification.

    Results: Correlation coefficients and significance values are shown the table. There was a positive relationship between consumption and the number of trade names (r = 0.11, P <0.01) for the pooled data. The relationship was strongest for FQs, but only in Europe (r = 0.62, P <0.01). Correlations were also significant for APs (r = 0.22, P<0.01) in Europe (0.38, P  =0.051) and Middle East and Africa (r=0.6, P =0.04) when stratifying by region, and for High-Income countries (r=0.29, P =0.018) when stratifying by income.

    Conclusion:  A positive correlation between community antibiotic consumption and the number of trade names was noted but the relationship varies by antibiotic class and is weaker in lower-income countries. The latter may imply that the presence of multiple brands is affected by the overall size of the market. The class differences may be due to the presence of more cheap generic options among aminopenicillins. 

    Carmina Mancenon, Operations Research and Financial Engineering Student at Princeton University, Operations Research and Financial Engineering, Princeton University, Princeton, NJ


    C. Mancenon, None

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