475. Care Seeking for RSV Disease in Preterm Infants Born at 32-35 Weeks Gestation: Findings from a Two-Year Cohort Study
Session: Poster Abstract Session: Prevention and Treatment of Viral Infections
Thursday, October 3, 2013
Room: The Moscone Center: Poster Hall C

Background: Preterm infants born at ≤35 weeks gestational age (wGA) are at elevated risk for severe disease due to respiratory syncytial virus (RSV). Limited data exist regarding the patterns of care for RSV disease in this population.

Methods: In the RSV Respiratory Events Among Preterm Infants Outcomes and Risk Tracking (REPORT) study, preterm infants ≤6 months of age born at 32–35 wGA not receiving RSV prophylaxis were prospectively enrolled from 188 US clinics and followed September–May of 2009–2010 or 2010–2011. Nasal and throat swabs were collected at outpatient visits for all respiratory illnesses and tested for RSV by qRT-PCR. Emergency department (ED) visits and hospitalizations during the study period for respiratory illnesses were collected from medical records. Events were linked if they occurred within 7 days. For respiratory ED visits and hospitalizations without RSV testing, the event was considered RSV-related if RSV was identified from specimens collected within 7 days of the event. Mutually-exclusive care seeking patterns for subjects with RSV were analyzed.

Results: 1646 subjects were enrolled. 288 had RSV-related medically-attended illness, of which 67% had outpatient visits only; 20% required hospitalization. Of those hospitalized for RSV (n=57), 25 (44%) lacked an RSV ED visit and 20 (35%) lacked an RSV outpatient visit. Of the 264 subjects with RSV-related outpatient illness, there were 309 RSV-related outpatient visits (1.2 visits per subject).

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Conclusion: For preterm infants 32–35 wGA requiring care for RSV disease, multiple patterns of care exist. Many (20%) required hospitalization. For preterm infants with RSV hospitalization, large proportions lacked an associated ED visit or an outpatient visit, underscoring the acute and potentially severe nature of RSV disease.

Eric A.F. Simoes, MB BS, DCH, MD1, Evan J. Anderson, MD2, Kellie Ryan, MPH3, Xionghua Wu, PhD4 and Christopher Ambrose, MD4, (1)University of Colorado School of Medicine, Aurora, CO, (2)Pediatrics and Medicine, Emory University School of Medicine, Atlanta, GA, (3)Medimmune, LLC, Gaithersburg, MD, (4)MedImmune, LLC, Gaithersburg, MD

Disclosures:

E. A. F. Simoes, MedImmune LLC: Grant Investigator, Research grant

E. J. Anderson, None

K. Ryan, MedImmune: Employee, Salary and Stock Options

X. Wu, MedImmune, LLC: Employee, Salary

C. Ambrose, MedImmune: Employee, Salary

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