1391. Effectiveness of a sporicidal peracetic acid/hydrogen peroxide-based daily disinfectant cleaner for disinfection of floors in rooms of patients with Clostridium difficile infection
Session: Poster Abstract Session: Clostridium difficile
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Background: Floors Clostridium difficile infection (CDI) isolation rooms may be contaminated with spores, but sporicidal disinfectants are not commonly used on floors in healthcare facilities. It is plausible that floors could contribute to C. difficile transmission because they are frequently contacted by surfaces that are subsequently touched by hands (e.g., shoes, socks, wheelchairs, portable equipment). OxyCide Daily Disinfectant CleanerTMis a sporicidal peracetic acid/hydrogen peroxide-based daily disinfectant cleaner that can be used on a wide range of surfaces including floors.

Methods: In the laboratory, we examined the efficacy of Oxycide versus a 1 to 10 dilution of household bleach for killing of C. difficile spores, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). In CDI isolation rooms, floors in bathrooms and adjacent to the patient bed were cultured for C. difficile, VRE, and MRSA. We compared the effectiveness of OxyCide versus a quaternary ammonium disinfectant for disinfection of floors contaminated with C. difficilespores.

Results: In the laboratory, Oxycide was as effective as bleach for disinfection of C. difficile spores, VRE, and MRSA, resulting in >5 log reductions in recovered counts of each organism. Of 54 CDI rooms cultured, contamination with C. difficile, VRE, and MRSA was detected in 7 (13%), 6 (11%), and 4 (7%). Oxycide eliminated C. difficilefrom contaminated floors, whereas a quaternary ammonium disinfectant resulted in redistribution of spores from contaminated to clean sites. There was no evidence of adverse effects to surfaces after multiple applications of Oxycide and no reported complaints from nursing staff or patients.

Conclusion: Floors in CDI rooms were frequently contaminated with C. difficile spores and other pathogens. OxyCide Daily Disinfectant Cleaner was as effective as bleach for in vitro killing of C. difficile spores, MRSA, and VRE, and it eradicated C. difficile spores from contaminated floors.

Abhishek Deshpande, M.D., Ph.D.1, Thriveen Mana, M.S., MBA1, Annette Jencson, BSMT(ASCP)SM, CIC2, Jennifer Cadnum, B.S.1, Brett Sitzlar, B.S.1, Dennis Fertelli1, Kelly Hurless, B.S.3, Sirisha Kundrapu, M.D.1, Venkata C.K. Sunkesula, M.D., M.S4 and Curtis Donskey, MD1,3, (1)Infectious Diseases, Case Western Reserve University, Cleveland, OH, (2)Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, (3)Louis Stokes Cleveland VA Medical Center, Cleveland, OH, (4)Case Western Reserve University, Cleveland, OH


A. Deshpande, None

T. Mana, None

A. Jencson, None

J. Cadnum, None

B. Sitzlar, None

D. Fertelli, None

K. Hurless, None

S. Kundrapu, None

V. C. K. Sunkesula, None

C. Donskey, EcoLab: Grant Investigator, Research grant

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