1281. Trends in Bacteroides Bacteremia
Session: Poster Abstract Session: Bacteremia and Endocarditis
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Background:

Bacteremia due to Bacteroides species is infrequent but results in significant morbidity and mortality. Recent studies have suggested an increase in the incidence of bacteremia secondary to Bacteroides species even though the overall incidence of anaerobic bacteremia may be decreasing. We performed a retrospective chart review to evaluate patient characteristics, risk factors, and outcomes associated with Bacteroides bacteremia.

Methods:

Patients admitted to Jersey Shore University Medical Center between 2005-2010 and had positive blood cultures with Bacteroides species were included. Data regarding patient demographics, length of stay, medical co-morbidities, potential risk factors, laboratory data, identification of Bacteroides species, type of antibiotic treatment received, and outcomes were collected. 

Results:

A total of 88 patient charts were reviewed.  Approximately 30% (26/88) of the patients had an underlying malignancy and 41% (36/88) of patients had undergone abdominal surgery. Average length of stay was approximately 20 days. The percentage of patients meeting the criteria for sepsis at the time of bacteremia was 66% (58/88) and the overall mortality rate was 31% (27/88). Of all the Bacteroides species, the Bacteroides fragilis group was the most common isolate. B. fragilis accounted for 42% (37/88) of patient isolates. Clinically significant polymicrobial bacteremia occurred in 16% (14/88) of the patients. Patients who had end stage renal disease on dialysis  or patients with central venous access were found to have significantly higher mortality rates, p- values of <0.001 and 0.005 respectively.  

Conclusion:

Patients who became bacteremic due to Bacteroides species had multiple co-morbidities and spent a long time in the hospital. As seen in other studies, patients had high rates of malignancy and recent abdominal surgery. We did find that having a central venous access catheter or having ESRD put patients at significantly higher risk for mortality.  Majority of the patients met criteria for sepsis at the time of bacteremia. Patient mortality rate following an episode of Bacteroides bacteremia remains very high, even with antimicrobial therapy.

Apurva Patel, MD1, Kathleen Casey, MD2, Marnie Rosenthal, DO, MPH3, Victor Johnson, MA4 and Yen Hong-Kuo, PhD4, (1)Medicine, Robert Wood Johnson Medical School, New Brunswick, NJ, (2)Jersey Shore Univ. Med. Center, Neptune, NJ, (3)Internal Medicine/Infectious Diseases, Jersey Shore University Medical Center, Neptune, NJ, (4)Jersey Shore Univ Medical Center, Neptune, NJ

Disclosures:

A. Patel, None

K. Casey, None

M. Rosenthal, None

V. Johnson, None

Y. Hong-Kuo, None

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