1782. Risk Factors for Cytomegalovirus Susceptibility Among Pregnant Women: An Epidemiological and Socio-demographic Study
Session: Poster Abstract Session: Viral Infections; Pathogenesis and Epidemiology
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Posters
  • poster cmv idsa 24.9 upload.pdf (1.0 MB)
  • Background:

    Congenital cytomegalovirus (CMV) infection is a leading cause of deafness and developmental delay in children. Recent advance in diagnostic and therapeutic modalities has generated a mounting interest for characterization of mothers susceptible for CMV. 

    Methods:

    In a tertiary mother-child care center, between April and November 2012, women were prospectively recruited at time of delivery. Knowledge about CMV and socio-demographic characteristics (age, country of birth, age at immigration, family income, having children at home and their daycare attendance, type of work) were collected with a standard questionnaire. Serum from first trimester of pregnancy was tested for CMV IgG.

    Results:

    Over the study period, 511 women were recruited with the following characteristics: median age was 32 years old [18-46], 225 (45.1%) were seronegative, 275 (55.2%) were born in Canada, 307 (61.4%) had a university degree, 104 (21.4%) had a family income < 30,000 $/year, and 422 (84.4%) did not have any knowledge about CMV. Among the 268 (53.8%) multiparous mothers, 147 (56.3%) had a child attending a day care center. 

    When comparing the CMV seronegative to seropositive mothers, the former group was more likely to be born in Canada (OR=8.26; 95%CI: 5.46-12.5) or to have immigrated at a younger age (OR=2.7; 95%CI: 1.23-6.09), to have less than two children at home  (OR=2.06; 95%CI: 1.28-3.33), and to have a higher socioeconomic status (OR=8.46; 95%CI: 4.62-15.36). A better knowledge about CMV was also found among the seronegative women (OR=2.44; 95% CI: 1.47-4.03). Age during pregnancy, working in a daycare, or having children in daycare was not associated with protection against CMV.

    Conclusion:

    Pregnant women were not aware of potential risk associated with CMV, although nearly half of them were at risk for primo infection. Information about CMV should be given to all pregnant women, while targeted serological screening could be offered to high risk groups.

    Sarah Wizman, MD1, Bruce Tapiero, MD1, Valérie Lamarre, MD2, Céline Rousseau, MD3, Marc Boucher, MD4 and Lubomir Alexandrov, PhD5, (1)Department of Pediatrics, Division of Infectious Diseases, CHU Sainte-Justine – University of Montreal, Montreal, QC, Canada, (2)CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada, (3)Department of Microbiology and Immunology, CHU Sainte-Justine – University of Montreal, Montreal, QC, Canada, (4)Obstetrics and Gynecology, CHU Sainte Justine, Montreal, QC, Canada, (5)Statistics and Clinical Research, CHU Sainte Justine, Montreal, QC, Canada

    Disclosures:

    S. Wizman, None

    B. Tapiero, None

    V. Lamarre, None

    C. Rousseau, None

    M. Boucher, None

    L. Alexandrov, None

    Findings in the abstracts are embargoed until 12:01 a.m. PST, Oct. 2nd with the exception of research findings presented at the IDWeek press conferences.