1482. Epidemiology of Viral Illnesses in Hospitalized Children in Amman, Jordan
Session: Poster Abstract Session: Global Health
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C

Background: The burden of disease attributable to viruses over time in hospitalized children in Amman, Jordan is poorly characterized.

Objective: To determine the burden of disease due to respiratory viruses in hospitalized children over a 2.5 year period.

Methods: We conducted a prospective year-round viral surveillance study in children <2 years of age admitted with respiratory symptoms and/or fever at the government-run hospital, Al-Basheer.  Surveillance was conducted Sunday-Thursday from 3/16/2010-9/10/2012. Clinical and demographic data were collected. Nasal/throat swabs were collected, placed into lysis buffer, aliquoted, and frozen at -80C. Specimen aliquots were shipped to Vanderbilt and tested by real-time RT-PCR for respiratory syncytial virus (RSV), metapneumovirus (HMPV), rhinovirus (HRV), influenza A and B, adenovirus, and parainfluenza viruses 1, 2, 3 (PIV1-3).

Results: A total of 2433 subjects were enrolled, with viral data available for 2429 subjects.  The median age was 3.5 months, with 60% males, 10% had an underlying medical condition, 2% attended day care, 76% subjects were exposed to smokers, 30% required oxygen, and 7% were admitted to the ICU.  Twenty-two children (0.9%) died.  980 tested positive for RSV, 892 for rhinovirus, 316 Adenovirus, 233 for HMPV, 97 PIV3, 31 PIV1 and 11 PIV2.   Co-detection was common, with RSV/HRV as the most common combination (n=243).  The most common admission diagnoses were the following: 806 (33%) bronchopneumonia, 412 (17%) with bronchiolitis, 683 (28%) rule out sepsis and 269 (11%) with pneumonia. Figure 1 represents the time-series of these viruses.

fig1.jpeg

Conclusion: There is a significant viral burden associated with hospitalizations among young children in Amman, Jordan year-round, with peaks in January and February.  RSV is the most common virus detected, followed by rhinovirus.

Najwa Khuri-Bulos, MD, CIC, FIDSA, Division of Infectious Disease, Jordan University Hospital, Jordan, Samir Faouri, MD, Al-Basheer, Amman, Jordan, Asem Shehabi, DSC, Jordan University, Amman, Jordan, Li Wang, M.S., Vanderbilt University, Nashville, TN, John Williams, MD, Vanderbilt Univ. Med. Ctr., Nashville, TN and Natasha Halasa, MD MPH, Vanderbilt University Medical Center, Nashville, TN

Disclosures:

N. Khuri-Bulos, None

S. Faouri, None

A. Shehabi, None

L. Wang, None

J. Williams, Quidel: Scientific Advisor, Consulting fee

N. Halasa, None

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