1633. Utility of Stool Microscopy and Culture for Diagnosis of Mycobacterial Infection
Session: Poster Abstract Session: Mycobacterial Infections
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Posters
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  • Background: The diagnosis of mycobacterial infection remains challenging. Sputum saving can be difficult in a significant proportion of patients. Alternative non-invasive means for diagnosis are needed.

    Methods: All patients hospitalized with suspected disseminated mycobacterial infections in 3 acute-general hospitals with stool samples collected for mycobacterial smear and culture (Lowenstein-Jensen) during 2006-2011 were reviewed. Patient characteristics, presentations, final diagnosis of MTB or NTM (based on non-fecal samples), and clinical outcomes were described. Performance of stool detection was analysed.

    Results: 78 patients were studied (Age 50+/-17, Male 65%, HIV/AIDS 18%); 60(77%) had gastrointestinal symptoms. 56 (71.8%) were diagnosed with mycobacterial infections (MTB 91%, GI tract MTB/NTM 23%). 19/56 (33.9%) had positive stool detection (smear+, n=6; culture+, n=17; MTB, n=14; NTM, n=5). None with non-mycobacterial diagnoses had positive stool results. Clinico-radiological GI tract disease was associated with a higher rate of stool detection (66.7% vs 30%). Positive stool detection was associated with a trend of higher risk of death/ICU admission (OR 3.6; 95% CI 0.9 to 14.7; p=0.07).

    Conclusion: Stool mycobacterial microscopy and culture is a potentially useful adjunctive tool for diagnosis of mycobacterial GI tract disease.

    Timothy Li1,2, Grace Lui1,2 and Nelson Lee1,2, (1)Prince of Wales Hospital, Shatin, Hong Kong, (2)The Chinese University of Hong Kong, Shatin, Hong Kong

    Disclosures:

    T. Li, None

    G. Lui, None

    N. Lee, None

    Findings in the abstracts are embargoed until 12:01 a.m. PST, Oct. 2nd with the exception of research findings presented at the IDWeek press conferences.