42238. Obese HIV Positive Females are at Decreased Risk for Development of Opportunistic Infections
Session: Poster Abstract Session: Medical Student Poster Session
Friday, October 4, 2013
Room: Yerba Buena Ballrooms
Background: Recent data suggest that HIV positive obese patients may be at a decreased risk for acquisition of Mycobacterium tuberculosis.  Data regarding obesity and the risk of other opportunistic infections (OIs) in HIV positive patients are lacking. The objective of this study was to define if an association exists between obesity and the development of OIs in HIV positive female patients.

Methods: This was a retrospective observational study of HIV positive female patients under care at the University of Louisville HIV Program from January 2006 to December 2012. OIs were defined according to CDC criteria.  Baseline demographic data on non-obese (BMI <30) and obese (BMI ≥30) patients and development of opportunistic infections were collected and compared using Chi-Squared tests.

Results: A total of 141 non-obese and 110 obese HIV positive female patients were evaluated.  A CD4 cell count of >200 was present in 121 (86%) non-obese patients and 98 (89%) obese patients (P=0.440).  HIV viral loads of <1000 copies were documented in 114 (81%) non-obese and 81 (74%) obese patients (P=0.173).  A total of 26 OIs were identified, 20 (14%) occurring in non-obese patients and 6 (5%) occurring in obese patients (P=0.001).

Conclusion: This study indicates that obese, HIV positive female patients are at decreased risk for development of OIs.  Defining the molecular mechanisms by which obesity influences the risk of OIs in HIV positive patients may help to develop novel therapeutic strategies.

Leslie Beavin, MD1, Diana Otero, MD1, Johnson Britto, MD1, Julio Ramirez, MD2, Timothy Wiemken, PhD2, Robert Kelley, PhD2 and Paula Peyrani, MD2, (1)Department of Medicine, University of Louisville, Louisville, KY, (2)Division of Infectious Diseases, University of Louisville, Louisville, KY

Disclosures:

L. Beavin, None

D. Otero, None

J. Britto, None

J. Ramirez, None

T. Wiemken, None

R. Kelley, None

P. Peyrani, None

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