1324. VITAMIN D3 LEVELS AND HEPATITIS B; IS THERE ANY RELATIONSHIP
Session: Poster Abstract Session: Biomarkers and Correlates of Protection
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Posters
  • hepatit B ve D vit poster.pdf (141.2 kB)
  • Background: Conducted studies have showed that vitamin D has very important biologic effects including cell differentiation, inhibition of proliferation and immune modulation. Vitamin D levels may affect the immune system and body’s response to viral infections like hepatitis B.

    Methods: Our aim in this study was to see weather or not there is a relationship between vitamin D levels and hepatitis B. Patients who came to Infectious Diseases outpatient clinic with chronic hepatitis B between January and March 2013 were chosen as cases. Controls were chosen among healthy individuals.

    Results: 90 cases and 86 controls were included in the period of study. 50% of the control and 43.3% of the case group were male. The mean age and vitamin D levels of the case and control groups were; 39.9±13.4 years, 37.1±13.4 years and 11.8±6.6 ng/ml, 30.2±16.1 ng/ml respectively. Vitamin D levels were significantly lower in the case group (p<0.001). Also vitamin D levels were statistically significantly lower in women. The mean vitamin D levels were 25.2±17.1 ng/ml in men and 16.9±12.4 ng/ml in women (p<0.001). The vitamin D levels were slightly higher in the patients under treatment (14.1±7 vs 11.1±6.4). There was no correlation between HBV DNA and vitamin D levels.

    Conclusion: The vitamin D3 levels were found significantly lower in hepatitis B patients while the ones on treatment had slightly higher levels; possibly because of these patients previously had vitamin D supplements on behalf of suspected tenofovir side effect of osteoporosis. Vitamin D supplement should be thought for chronic hepatitis B patients.

    Aslihan Candevir Ulu1, Behice Kurtaran2, Selcuk Nazik3, Ozay Akyildiz2, Ayse Seza Inal2, Suheyla Komur4, Hasan Salih Zeki Aksu2 and Yesim Tasova2, (1)Infectious Diseases, Cukurova University, Adana, Turkey, (2)Cukurova University, Adana, Turkey, (3)Çukurova University, Adana, Turkey, (4)Cukurova University, adana, Turkey

    Disclosures:

    A. Candevir Ulu, None

    B. Kurtaran, None

    S. Nazik, None

    O. Akyildiz, None

    A. S. Inal, None

    S. Komur, None

    H. S. Z. Aksu, None

    Y. Tasova, None

    Findings in the abstracts are embargoed until 12:01 a.m. PST, Oct. 2nd with the exception of research findings presented at the IDWeek press conferences.