1707. Hydrogen peroxide vapor (HPV) room disinfection significantly reduces the rate of C. Difficile infection
Session: Poster Abstract Session: Role of the Healthcare Environment in HAIs
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
  • 130905 Flagstaff ID week poster.pdf (155.4 kB)
  • Hydrogen peroxide vapor (HPV) room disinfection significantly reduces the rate of C. difficile infection


    Kim Horn, Diana Rolland

    Flagstaff Medical Center, Flagstaff, Arizona

    Background: Clostridum difficile is an important cause of antibiotic-associated diarrhea in hospitalized patients. C. difficile infection (CDI) is an important cause of morbidity and mortality, particularly in older patients. During episodes of diarrhea, C. difficile spores are shed into the environment and can survival for extended periods of time. Admission to a room previously occupied by a patient with C. difficile increases the chances of acquisition CDI.

    Methods: Hydrogen peroxide vapor (HPV) room disinfection was implemented across the hospital for the terminal room disinfection upon discharge of patients with CDI starting in October 2011. The percentage of rooms receiving terminal disinfection with (HPV) upon discharge was calculated from January to September 2011. The rate of CDI was compared for the 12 months prior to the implementation of HPV with the 12 months after HPV. The monthly handwashing rate was determined by handwashing observations with 30 observations per unit.

    Results: The mean monthly CDI rate fell from 1.3 per 1000 patient days in the 12 months prior to HPV to 0.7 in the first 12 months of HPV use (p<0.001.) 89% of 152 CDI discharges were disinfected using HPV. Compliance with hand hygiene increased from 78% to 85% comparing the same periods; this difference was not statistically significant (p=0.21).

    Conclusion: We showed that the terminal room disinfection with HPV of patients discharged with CDI was associated with a significant reduction in the rate of CDI acquisition. We also identified a non-significant increase in hand hygiene in the same period, which could confound the apparent association. Rooms vacated by patients with CDI were prioritized for HPV, meaning that only a small number were missed. Hospitals should consider the use of HPV to augment terminal disinfection of rooms vacated by patients with CDI.

    Kimberly Horn, RN, BS, MPH, CIC, Infection Control, Flagstaff Medical Center, Flagstaff, AZ


    K. Horn, None

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