1403. Treatment approaches for relapsing Clostridium difficile infection (RCDI) among Infectious Disease Physicians
Session: Poster Abstract Session: Clostridium difficile
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
  • C diff ID Week 2013.pdf (657.8 kB)
  • Background: Clostridium difficile infection (CDI) continues to increase in incidence and severity, and was the most common nosocomial infection in the U.S. in 2010. Most cases of CDI respond to a standard course of antibiotics, but recurrent C. difficile infections (RCDI) are increasingly common.

    Methods: An electronic survey was conducted among members of the Emerging Infections Network (EIN) in October 2012. Respondents were asked to answer specific questions about their treatment approaches toward patients with CDI, including fecal microbiota transplantation (FMT).

    Results: The overall response rate was 621/1,212 (51%). The vast majority of respondents had cared for small to moderate numbers of patients with CDI over the prior 6 months, and reported relapse rates were consistent with published data. Preferred treatment regimens for RCDI showed significant variance from recommendations published in national guidelines. Eighty percent (424/527) of the respondents would consider FMT for patients with RCDI, and 107 of 149 respondents (72%) had actually treated one or more patients with FMT during the preceding year. However, significant barriers to institutional adoption of FMT remain for many respondents, despite very good success rates with its use.

    Conclusion: Physicians who regularly care for patients with CDI use a variety of treatment approaches for treating severe or recurrent CDI cases. The results of our survey demonstrates that FMT is utilized by a growing number of infectious disease providers as an effective and safe treatment alternative for patients with multiple recurrences of Clostridium difficile infection.

    Judy A Streit, MD, Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA


    J. A. Streit, None

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