760. USE OF POLIMIXIN B AND E AT THE CENTRAL MILITARY HOSPITAL IN COLOMBIA:  A FOUR YEAR EXPERIENCE
Session: Poster Abstract Session: Antimicrobials: Treatment of HAI and Resistant Infections
Friday, October 4, 2013
Room: The Moscone Center: Poster Hall C
Posters
  • POSTER ID WEEK 2013 FINAL .pdf (258.6 kB)
  • Background: The polymyxins are used in the setting of multi-drug resistant gram-negative infections with a limited number of contemporary studies issuing addressing its clinical aspects, with different nephrotoxicity and cure rates between them. This study is conducted to assess the safety and efficacy of polymyxins in the Hospital Militar Central population.

    Material and Methods: 90 patients with multi-drug resistant gram negative infections were identified at the hospital’s pharmacy registries for having received Polymicyn B or E (colistin). We retrospectively evaluated the clinical outcomes and adverse effects related with the endovenous use of the drug.

    Results: The mean age of analyzed population was 45,75 ± 2,349, 71% were men, and most were surgical patients (51%), 68% were hospitalized in the ICU and 55% were under mechanical ventilation. Global mortality reached 26.9%, with cure of 69.6%  and with an incidence of acute kidney injury of 25.5%. Mean creatinine during the period of renal lesion was 2,8717 ± 0.225 that was present at 8,52 ± 1,48 from the beginning of polymyxin administration.    

    Conclusion: In conclusion, the polymyxins in our institution have a good activity against multi-drug resistant gram negative bacteria reflected in a cure of 69.6% and mortality of 26.9%, which are comparable with those described in other series, with a frequency of acute kidney injury of 26%, greater than those previously reported, which suggest a need for a narrow clinical following.

    Carlos Morales Sr., ESPECIALIST IN INTERNAL MEDICINE1, Carlos Morales Sr., ESPECIALIST IN INTERNAL MEDICINE1, Carlos Perez2, Heison Mora Sr., ESPECIALIST IN INTERNAL MEDICINE1,2 and GRUPO DE INVESTIGACION EN ENFERMEDADES TROPICALES E INFECCIOSAS, GETI, HMC UNMG, (1)Internal Medicine, CENTRAL MILITARY HOSPITAL, BOGOTA, Colombia, (2)Universidad Militar Nueva Granada, Bogota, Colombia

    Disclosures:

    C. Morales Sr., None

    C. Morales Sr., None

    C. Perez, None

    H. Mora Sr., None

    Findings in the abstracts are embargoed until 12:01 a.m. PST, Oct. 2nd with the exception of research findings presented at the IDWeek press conferences.