Program Schedule

Point-of-Care Diagnostics for Use in OIs

Session: Symposium: New Issues in HIV-Related Opportunistic Infection Management
Saturday, October 11, 2014: 2:30 PM
Room: The Pennsylvania Convention Center: 118-ABC
Yukari Manabe, MD, Medicine, Johns Hopkins University, Baltimore, MD

Yukari C. Manabe, MD
Yale College
Columbia College of Physicians & Surgeons, New York, NY
American Board of Internal Medicine, Board Certified in Internal Medicine
American Board of Internal Medicine, Board Certified in Infectious Diseases
Positions and Honors
1991-94 Internal Medicine Residency; Johns Hopkins Hospital, Department of Medicine
1994-95 Internist, Department of Medicine, FHP Guam, full-time
1995-96 Staff internist, Department of Medicine, The Doctors Clinic, Tamuning Guam, full-time
1996-99 Infectious Diseases Fellowship; Johns Hopkins Hospital, Division of Infectious Diseases
Assistant Professor, JHU School of Medicine, Baltimore, MD
2000- present
Secondary appointment in Department of International Health,
Johns Hopkins Bloomberg School of Public Health
2003 - present Secondary appointment in Department of Molecular Microbiology and Immunology
Johns Hopkins Bloomberg School of Public Health
October, 2007
Associate Medical Director, MU-JHU Core Lab
Infectious Diseases Institute, Makerere University Medical School, Kampala, Uganda
February, 2008
Associate Professor, Department of Medicine, JHU
June, 2008
Head of Research, Infectious Diseases Institute
Publications (selected)
Manabe YC, et al. Attenuation of Virulence in Mycobacterium tuberculosis Expressing a Constitutively Active Iron Repressor. PNAS 1999; 96: 12844-12848.
Manabe YC, et al. Conditional sigma Factor Expression, Using the Inducible Acetamidase Promoter, Reveals that the Mycobacterium tuberculosis sigF Gene Modulated the Expression of the 16kDa Alpha-Crystallin Homologue. J Bacteriol 1999; 181: 7629-7633.
Manabe YC, Dannenberg AM, Bishai WR. What We Can Learn from the Mycobacterium tuberculosis Genome Sequencing Project. Int J of Tuberc Lung Dis 2000; 4(2): S18-S23.
Manabe YC & Bishai WR. Latent Mycobacterium tuberculosis -- persistence, patience, and winning by waiting. Nature Med 2000; 6: 1327-1329.
Manabe YC, Scott CP, Bishai WR. Naturally attenuated, orally administered Mycobacterium microti as a tuberculosis vaccine better than subcutaneous M. bovis BCG. Infect Immun 2002; 70: 1566-70.
Kaushal D, Schroeder BG, Tyagi S, Yoshimatsu T, Scott C, Ko C, Carpenter L, Mehrotra J, Manabe YC Fleischmann RD, Bishai WR. Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. PNAS 2002 ; 99: 8330-5.
Scott CP, dos Anjos Filho L, Carvalho de Queiroz Mello F, Thornton CG, Bishai WR, Fonseca LS, Kritski AL, Chaisson E, Manabe YC. Comparison of C18-Carboxypropylbetaine (CB-18) and Standard NALC/NaOH Processing of Respiratory Specimens for Increasing Tuberculosis Smear Sensitivity in an Endemic, Urban Area. J Clin Micro 2002;40(9):p3219-3222.
Ando, M, Manabe, YC, Converse, PJ, Miyazaki, E, Harrison, R, Murphy, JR, Bishai, WR. Characterization of the role of the divalent metal ion-dependent transcriptional repressor MntR in the virulence of Staphylococcus aureus. Infect Immun 2003; 71(5): p2584-2590.
Manabe YC, et al. Different Strains of Mycobacterium tuberculosis Cause Varied Spectrums of Disease in the Rabbit Model of Tuberculosis. Infect Immun 2003; 71(10): p6004-6011.
Geiman DE, Kaushal D, Ko C, Tyagi SK, Manabe YC, Morrison NE, Converse PJ, Chen P, Bishai WR. Attenuation of late-stage disease in mice infected by the Mtb mutant lacking the SigF alternate sigma factor and identification of SigF-dependent genes by microarray analysis. Infect Immun 2004; 72(3): p1733-45.

Findings in the abstracts are embargoed until 12:01 a.m. EDT, Oct. 8th with the exception of research findings presented at the IDWeek press conferences.

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