Program Schedule

793
Incidence of Cardiovascular Events in Patients with Influenza Pneumonia or Pneumonia Due to Other Etiologies

Session: Poster Abstract Session: Clinical Respiratory Infections
Friday, October 10, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
Posters
  • Cardiovascular Events in Flu Pneumonia. Poster IDWeek 2014.pdf (227.9 kB)
  • Background:

    Cardiovascular diseases, influenza, and pneumonia are leading causes of morbidity and mortality worldwide. Cardiovascular events (CVE) are common during the clinical course of pneumonia. Investigators have documented an increased incidence of cardiovascular events and associated mortality during the influenza season as well. However it is unknown as to if these associations are due to all-cause pneumonia or influenza-specific pneumonia. The Community-Acquired Pneumonia Organization (CAPO) is an international observational study that assesses the management of hospitalized patients with community-acquired pneumonia (CAP).  Using the centralized CAPO database we decided to conduct this study with the aim to compare the incidence of cardiovascular events in patients with pneumonia due to influenza or pneumonia due to other etiologies.

    Methods:

    This was a secondary analysis of the CAPO study database. Influenza was identified via PCR.  Patients with CAP were classified into two groups: CAPFlu (+) or CAPFlu (-) based on influenza PCR results. The following CVE were recorded during hospitalization: arrhythmias, congestive heart failure, acute myocardial infarction and pulmonary embolism. Fisher’s exact test was used to compare cardiovascular events.

    Results:

    A total of 800 patients with CAP were included in the study. Of the 112 CAPFlu (+) patients, 14 (13%) had a CVE, while of the 688 CAPFlu (-) patients, 77(11%) had a CVE (p=0.75). New serious arrhythmia and acute worsening of a long-term arrhythmia combined were the most frequent CVE in both groups [9% CAPFlu (+) vs. 5% CAPFlu (-)].

    Conclusion:

    This study indicates that there is no difference in the incidence of cardiovascular events in patients with pneumonia due to influenza or pneumonia due to other etiologies. The inflammatory response to pneumonia is the primary driver for CVE, regardless of etiology.

    Jorge Perez San Juan, MD, Daniel Curran, MD, Lisandra Rodriguez Hernandez, MD, Robert Kelley, PhD, Timothy L. Wiemken, PhD, MPH, CIC, Forest Arnold, DO, Raul Nakamatsu, MD, Anupama Raghuram, MD, Paula Peyrani, MD, James Summersgill, PhD, Ruth Carrico, PhD, RN, FSHEA, CIC and Julio a. Ramirez, MD, Division of Infectious Diseases, University of Louisville, Louisville, KY

    Disclosures:

    J. Perez San Juan, None

    D. Curran, None

    L. Rodriguez Hernandez, None

    R. Kelley, None

    T. L. Wiemken, None

    F. Arnold, None

    R. Nakamatsu, None

    A. Raghuram, None

    P. Peyrani, None

    J. Summersgill, None

    R. Carrico, None

    J. A. Ramirez, None

    Findings in the abstracts are embargoed until 12:01 a.m. EDT, Oct. 8th with the exception of research findings presented at the IDWeek press conferences.

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