Program Schedule

1307
Bacterial meningitis

Session: Symposium: Big Beasts of Infectious Disease
Saturday, October 11, 2014: 11:00 AM
Room: The Pennsylvania Convention Center: 118-ABC
Diederik Van De Beek, MD, PhD, Academic Medical Center, Amsterdam, Netherlands

Diederik van de Beek
Male, 35 years, born May 18th 1974, Huissen, The Netherlands

1992-1999 Medical Degree (M.D.)
Faculty of Medicine, University of Amsterdam, Amsterdam, the Netherlands.

2000-2006 Board Certification Neurology
Academic Medical Center, Amsterdam, the Netherlands.

2004 Doctorate (Ph.D.)
Thesis entitled “Bacterial meningitis in adults” (University of Amsterdam, 2004; supervisor, Prof. Dr. M. Vermeulen).

2006-2007 Visiting Scientist, Mayo Clinic, Rochester, USA

2007- Current position
I have a fixed position as neurologist at the Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

15 Landmark papers
1. Fransen F, Heckenberg SG, Hamstra HJ, Feller M, Boog C, van Putten J, van de Beek D, van der Ende A, van der Ley P. Naturally occurring lipid A mutants in Neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy. PloS Pathogens 2009; 5: e1000396.
2. Brouwer MC, de Gans J, Heckenberg SGB, Zwinderman AH, van der Poll T, van de Beek D. Host genetic susceptibility to pneumococcal and meningococcal disease: systematic review and meta-analysis. Lancet Infect Dis 2009; 9: 31-44.
3. Heckenberg SGB, de Gans J, Brouwer MC, Weisfelt M, Piet JR, Spanjaard L, van der Ende A, van de Beek D. Clinical features, outcome and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study. Medicine (Baltimore) 2008; 87:185-92.
4. Fitch MT, van de Beek D. Steroids in central nervous system infectious diseases: new indications for an old therapy. Nat Rev Neurol 2008; 4: 97-104.
5. Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J. A risk score for unfavorable outcome in adults with bacterial meningitis. Ann Neurol 2008; 63: 90-7.
6. Fitch M, van de Beek D. Emergency diagnosis and treatment of adult meningitis. Lancet Infect Dis 2007; 7: 191-200.
7. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids in acute bacterial meningitis. Cochrane Database Syst Rev 2007; 1: CD004305.
8. van de Beek D, Weisfelt M, de Gans J, Tunkel AR, Wijdicks EFM. Drug insight: adjunctive therapies in adults with bacterial meningitis. Nat Rev Neurol 2006; 2: 504-16.
9. Weisfelt M, Hoogman M, van de Beek D, de Gans J, Dreschler WA, Schmand B. Dexamethasone and long-term outcome in adults with bacterial meningitis. Ann Neurol 2006; 60: 456-468.
10. Weisfelt M, de Gans J, van der Poll T, van de Beek D. Pneumococcal meningitis in adults: new approaches to management and prevention. Lancet Neurol 2006; 5: 332-42.
11. Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J. Clinical features, complications and outcome in adults with pneumococcal meningitis: a prospective series of 352 cases. Lancet Neurol 2006; 5: 332-42.
12. van de Beek D, de Gans J, Tunkel AR, Wijdicks EFM. Community-acquired bacterial meningitis in adults. N Engl J Med 2006; 354: 46-55.
13. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351: 1849-59.
14. van de Beek D, de Gans J, McIntyre P, Prasad K. Steroids in adults with acute bacterial meningitis: a systematic review. Lancet Infect Dis 2004; 4: 139-43.
15. de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Engl J Med 2002; 347: 1549-56.

5 Book chapters
1. Tunkel AR, van de Beek D, Scheld MW. Acute meningitis. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practices of Infectious Diseases. 7th ed. Philadelphia, USA: Churchill Living



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