Program Schedule

1656
ONE CASE OF PEDIATRIC SEVEREPDEUDOMEMBRANOUS ENTERITIS TREATED WITH FECAL MICROBIOTA TRANSPLANTATION AND LITERATURE REVIEW

Session: Poster Abstract Session: Clostridium difficile Infection: Epidemiology, Presentation, Treatment
Saturday, October 11, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
Background:  Pseudomembranous enteritis (PME) is an acute inflammatory bowel disease affecting pediatric population. The aim of this study was to discuss the characteristics, diagnosis, and management of pediatric PME, and the potential possibility of fecal microbiota transplantation (FMT) application in pediatric PME.

Methods: The clinical manifestations, laboratory testing, diagnosis, and treatment of one case with severe pediatric PME were reviewed, analyzed, and summarized.Meanwhile, associated literatures of FMT were reviewed in this article.

Results: 1.A 13-month-old boy admitted with 2-month diarrhea, half-month edema, hypoalbuminemia, and malnutrition. At the beginning, exploratory laparotomy and high ligation of inguinal hernia was performed. Multiple broad-spectrum antibiotics were daily introduced to this patient during 2 months. Protein-losing gastroenteropathy, severe PME, electrolyte disturbance, and malnutrition were diagnosed and treated accordingly. For PME, the patient was treated with 10-day oral metronidazole plus vancomycin for twice, then FMT was performed via nasal jejunal feeding tube. The patient completely recovered and released.2.In total 143 published articles were reviewed, 217 cases of recurrent Clostridium difficile infection, PME, and antibiotic associated diarrhae using FMT were included. 191 (88.0%) patients recovered at the first time treated with FMT. 8 of 9 (88.9%) recurrent patients who received the second FMT recovered. There was only one report of one pediatric PME case treated with FMT.

Conclusion: It needs to pay more attention to pediatric PME during clinical practice. Although, FMT might be another practicable option for severe or recurrent PME cases that was failed with empirical therapy, it is recommend that this strategy should be taken cautiously to the complicated cases of PME until more data generated from randomized studies can confirm the safety and effectiveness of FMT.

Yongmei Xiao, M.D.1, Jiayi Wang1, Yanran Che1, Haifeng Liu1, Hong Zhang2, Yongchen Yang2, Zhihong Hu1 and Ting Zhang, M.D., Ph.D.1, (1)Department of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Shanghai, Shanghai, China, (2)Department of Laboratory Medicine, Children's Hospital of Shanghai, Shanghai, China

Disclosures:

Y. Xiao, None

J. Wang, None

Y. Che, None

H. Liu, None

H. Zhang, None

Y. Yang, None

Z. Hu, None

T. Zhang, None

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