Estimates of Pertussis Vaccine Effectiveness in Air Force Pediatric Dependents Seen at Military Treatment Facilities
Methods: We conducted a test-negative, case-control study among Air Force pediatric dependents seen at military treatment facilities from 2011-2013, comparing cases with a positive pertussis test result and/or culture to controls who received the same lab tests with a negative result. Twelve years (2002-2013) of historical pertussis vaccination data were examined for all cases and controls. Our study population was categorized by age group and vaccination status based on the Centers for Disease Control and Prevention recommended pertussis vaccination schedule. VE was calculated with respect to vaccination status and pertussis lab results.
Results: We compared 27 pertussis laboratory positive cases with 974 pertussis laboratory negative controls, 2 months old to < 12 years old. Comparing completely vaccinated to non-vaccinated patients, overall VE was 78.26%. Among children 2 months to < 6 years old, the VE was 94.23%. VE was highest amongst those 15 months old to < 6 years old (97.55%). Children 6 years old to < 12 years had the lowest VE (48.48%). Comparing partially vaccinated patients to non-vaccinated patients yielded 64.24% overall VE.
Conclusion: Pertussis vaccination was effective at preventing laboratory confirmed pertussis among our Air Force pediatric dependent population, with highest protection among completely vaccinated, young children. We found pertussis VE varied by age groups. Our overall calculated pertussis VE corroborates other pertussis VE studies looking at similar age groups.
J. Escobar, None
S. Ruiz, None