Program Schedule

1747
Are Screening Blitzes Contributing to the Observed Trends in Syphilis Outbreaks in Urban Men Who Have Sex with Men?

Session: Poster Abstract Session: Sexually Transmitted Infections: Epidemiology, Screening, and Management
Saturday, October 11, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC

Background: Syphilis has reemerged as a significant public health problem in many urban centers in North America, with outbreaks focused in men who sex with men (MSM). In many jurisdictions, these recent outbreaks have displayed a stereotyped behavior, with initial increases in diagnosed cases followed by a period of plateau or decrease, and a subsequent resurgence in rates. We hypothesized that intensive screen and treat campaigns ('blitzes') may be contributing to observed syphilis trends.

Methods: We developed a dynamic compartmental mathematical model of syphilis transmission in a population of sexually active MSM. Parameters were derived from the biomedical literature and by model calibration. We assumed that base case annual screening coverage was 30%. We modeled a one-year transient increase in syphilis screening, with population coverage of screening during this blitz period ranging from 50-90%, followed by a return to base case screening levels. We evaluated the impact of screening blitzes on model-projected syphilis incidence and incidence of diagnosed early syphilis over a 10-year period following the transient screening increase.

Results: Blitzes were projected to result in transient stabilization (blitz coverage of 50-60%) or decreases (blitz coverage of ³70%) in diagnosed cases and syphilis incidence. These declines were followed by rebounds in disease occurrence. Diagnoses of early syphilis cases were projected to exceed base case levels by the end of the evaluation period, regardless of blitz intensity. At the end of the evaluation period, syphilis incidence was projected to reach higher levels (4-28% relative to base case) than in the absence of intervention (Figure). The overall impact on disease burden was minimal, with no significant change in cumulative syphilis incidence in the post-intervention period.

Conclusion: Sharp increases in syphilis screening as a result of screening blitzes may account for observed trends in syphilis diagnoses in MSM. Such interventions are not projected to reduce disease burden in the long-term, suggesting that efforts to achieve regular, sustained screening of at-risk individuals are likely to be more impactful for outbreak control.

Ashleigh Tuite, MPH, MSc1,2 and David N. Fisman, MD, MPH2,3, (1)Institute of Medical Science, University of Toronto, Toronto, ON, Canada, (2)Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, (3)Department of Medicine, Univeristy of Toronto, Toronto, ON, Canada

Disclosures:

A. Tuite, None

D. N. Fisman, None

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