Program Schedule

Osteoarticular Tuberculosis in an Inner City University Medical Center: Epidemiology and Outcomes

Session: Poster Abstract Session: Approach to Clinical Infections
Friday, October 10, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
  • OA TB Poster IDWeek 2014 v Sep 12.pdf (220.2 kB)
  • Background: Osteoarticular tuberculosis (TB) is an uncommon form of extra-pulmonary TB and the diagnosis challenging.  The goal of our study was to obtain a better understanding of the epidemiology and outcome of this infection in our inner-city patient population.

    Methods: We retrospectively reviewed the records of patients treated for osteoarticular TB at University Hospital in Newark, NJ from 2000-2012. Microbiology laboratory records were used to identify patients with positive bone/joint cultures for Mycobacterium tuberculosis (MTB).  Specimen source, organisms isolated, MTB PCR results, and susceptibilities were recorded. The following data was extracted from the electronic medical record of case patients: demographics, comorbid conditions, history of active or latent TB, site of infection, symptoms and duration, surgical procedures, imaging studies, ESR, CRP, histopathology, anti-TB regimen, duration of therapy and outcomes.

    Results: There were 24 patients with musculoskeletal specimens positive for MTB representing 4.2% of all positive MTB specimens. 20 infections were extra-spinal (83%) with foot/ankle most frequent (21%); 8 were spinal.  Osteomyelitis was present in 17; 9 had joint involvement; 10 abscess formation. Pain (92%), swelling (50%) and weight loss (21%) were the most frequent presenting symptoms; fever occurred in only 8%. Mean duration of symptoms was 5.9 mos; mean age 38 yrs. 71% of patients were men.  The majority of patients were immigrants (75%). Prior history of pulmonary TB was present in 5 patients; 7 were diagnosed with pulmonary TB concomitantly; 8 had bacterial infection. Comorbid conditions included HIV, IVDU, and HCV. Mean ESR was 55; CRP 55. Mean time to culture diagnosis was 45 days. 19 MTB isolates were fully susceptible; 4 had 1-drug resistance; 2 had 3-drug resistance; 1 had multidrug resistance. All patients initially received 4 anti-TB drugs. 75% of patients required surgery; 2 patients amputation. 9 patients were cured, 6 improved, 2 failed, 1 died, 6 were lost to follow up.

    Conclusion: Osteoarticular TB in our patient population is uncommon and occurs most frequently in immigrant men.  The spine and foot/ankle are the most common sites of infection.  Diagnosis is often delayed and outcomes variable.  A high index of suspicion is needed to establish a timely diagnosis and provide appropriate therapy.

    Margaret Aldrich, MD1, Mukaddes Yasar, MD2 and Lisa Dever, MD2, (1)Medicine & Pediatrics, Rutgers New Jersey Medical School, Newark, NJ, (2)Division of Infectious Diseases, Rutgers New Jersey Medical School, Newark, NJ


    M. Aldrich, None

    M. Yasar, None

    L. Dever, None

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