Factors Associated with Hospital Length of Stay among Cancer Patients with Febrile Neutropenia
Methods: A prospective cohort study was performed at a single tertiary referral hospital in southern Brazil from October 2009 to August 2011. All adult cancer patients with febrile neutropenia admitted consecutively to the hematology ward were evaluated. A stepwise negative binomial regression was conducted to identify risk factors for prolonged hospital length of stay.
Results: In total, 307 cases of febrile neutropenia (in 169 patients) were evaluated. The overall median hospital length of stay was 16 days (interquartile range 18 days). After multiple negative binomial regression analysis was performed, hematologic neoplasm (P=0.003), high-dose chemotherapy regimens (P<0.001), duration of neutropenia (P<0.001), and bloodstream infection involving Gram-negative multi-drug resistant bacteria (P=0.003) were independently and directly associated with prolonged hospital length of stay in patients with febrile neutropenia.
Conclusion: Hematologic neoplasms, high-dose chemotherapy regimens, prolonged periods of neutropenia, and bloodstream infection by Gram-negative multi-drug resistant bacteria increase risk for prolonged hospital length of stay among adult cancer patients with febrile neutropenia.