Trends of Antibiotic Consumption in Korea according to Nation-wide Reimbursement Data (2008-2012): A Population-Based Epidemiologic Study
Methods: This population-based descriptive study was conducted using data from nationwide health insurance claims between 2008 and 2012. Data of systemic antibiotics for ambulatory and hospital care were collected using measurement units of the Defined Daily Dose (DDD)/1,000 populations per day according to the Anatomical Therapeutic Chemical classification. All of the analyses were performed with SAS 9.2.
Results: During study period, total consumption of systemic antibiotics showed stable trend as follows: 21.68 in 2008, 22.46 in 2009, 22.99 in 2010, 22.60 in 2011, and 23.12 in 2012. Of the total antibiotics, 83.65 % are used in the outpatients. During recent five years, penicillins were the most commonly used antibiotics, followed by second generation cephalosporins, macrolides, and fluoroquinolones. In time series analysis with an ARIMA model, total antibiotic consumption demonstrated the significant seasonality (P<0.001). Total antibiotic consumption was more frequently prescribed in the influenza season than in the non-influenza season (AUD, 1.98±0.16 vs 1.81±0.18, P<0.001). In a regression model with autoregressive errors, aminoglycosides consumption has been continuously decreased during recent five years (P<0.001). Meanwhile, main antibiotic classes for infections caused by multi-drug-resistant microorganisms and metronidazole showed the upward trend (P<0.001). Differences by age groups and types of healthcare institution were observed among antibiotic classes. Antibiotics used most frequently in surgical subjects to an evaluation of antibiotic prescription relevance have decreased from 2008 to 2012, in contrast with those to a non-evaluation (P<0.001).
Conclusion: In conclusion, this study suggested that consumption of the broader spectrum antibiotics has been increased recently and showed the effect of appropriate public health policy associated with perioperative antibiotic prescription.
Y. K. Yoon,
H. An, None
B. C. Chun, None
J. W. Sohn, None
M. J. KIM, None