Program Schedule

341
Heterogeneous regional distribution of nosocomial infections due to ESBL-producing Enterobacteriaceae in Germany: Data from the German National Reference Center for the Surveillance of Nosocomial Infections (KISS)

Session: Poster Abstract Session: Multidrug-resistant Organisms: Epidemiology and Prevention
Thursday, October 9, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
Background:

Surveillance systems for hospital infections are reporting increasing rates of extended-spectrum beta-lactamase (ESBL)-positive Enterobacteriaceae in Europe. We aimed to perform a national survey on the trend and regional distribution of nosocomial infections due to ESBL-positive Enterobacteriaceae in German hospitals.

Methods:

Data from two components of the German national nosocomial infection surveillance system (KISS) from 2007 to 2012 were used for this analysis. The data derive from intensive care units (ITS-KISS) and surgical departments (OP-KISS). Independent factors determining the proportion of ESBL-positive Enterobacteriaceae among nosocomial infections due to Enterobactiaceae and changes in its regional distribution (broken down into German federal states) were calculated by regression analysis.

Results:

From 2007 to 2012, the data showed a significantly growing proportion of ESBL-producing Enterobacteriaceae in surgical site infections (p=0.003), urinary tract infections (p<0.001) and lower respiratory tract infections (p<0.001) due to Enterobacteriaceae. Factors independently associated with a growing proportion were: Thuringia (p=0.009; OR 1.53), North Rhine-Westphalia (p<0.001; OR 1.41) and general surgery ward (p=0.002; OR 1.47).

Conclusion:

The proportion of ESBL-positive Enterobacteriaceae from nosocomial infections has significantly increased in Germany over the last six years. Especially hospitals in Central Germany and surgical departments are affected by this development.

Rasmus Leistner, MD1,2, Christin Schröder3, Christine Geffers, MD3, Ann-Christin Breier, MD4, Petra Gastmeier, MD1,5 and Michael Behnke, PhD1,2, (1)Institute of Hygiene and Environmental Medicine, Charité – University Medicine Berlin, Berlin, Germany, (2)German National Reference Center for the Surveillance of Nosocomial Infections, Berlin, Germany, (3)Institute of Hygiene and Environmental Medicine, Charite University Medicine Berlin, Berlin, Germany, (4)Institute of Hygiene and Environmental Medicine, Charite University Medicine Berlin, b, Germany, (5)Institute of Hygiene and Environmental Medicine, Berlin, Germany

Disclosures:

R. Leistner, None

C. Schröder, None

C. Geffers, None

A. C. Breier, None

P. Gastmeier, None

M. Behnke, None

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