Program Schedule

797
Viral co-infections in hospitalized patients with respiratory tract infections

Session: Poster Abstract Session: Clinical Respiratory Infections
Friday, October 10, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
Posters
  • Poster, 2014 widad1.pdf (5.3 MB)
  • Background: Improvement in molecular technologies in the past ten years allow us to simultaneously test respiratory viruses such as human rhinovirus (HRV), respiratory syncytial virus (RSV), influenza A virus (FluA), parainfluenza virus-1 (PIV-1), parainfluenza virus-3 (PIV-3),  human coronavirus-OC43 (HCoV-OC43), human coronavirus-229E (HCoV-229E), adenoviruses (AdV) and a panel of newly discovered viruses such as human metapneumovirus (hMPV), HCoV -NL63, human bocavirus (Boca), human polyomavirus KI (KIV) and human polyomavirus WU (WUV). The simultaneous detection of a broad spectrum of viruses allows the identification of viral co-infection in upper respiratory infections (URTI) and lower respiratory tract infections (LRTI). In this study establishing a link between viral co-infections and an increase in disease severity can be thought-provoking.

    Methods: The aim of this study is to investigate the role of viral co-infection in patients with respiratory tract infections (RTI) by using real time PCR techniques.

    Results: In total, 934 hospitalised patients aged between 3 days and 80 years were screened over a three years period, from September 2010 to September 2013. Among the 351 patients diagnosed with viral infections, HRV was detected in 41.9%, FluA virus in 15.1% and RSV in 13.1%. Viral co-infection was detected in 49 patients (14%) with HRV being the most common virus associated with co-infection (26 patients or 7.4%), followed by AdV (14 patients or 4%) and HCoV-OC43 (12 patients or 3.4%). It was interesting to note that three patients had three viral co-infections. Among the 49 co-infected patients viral co-infections were common among those aged less than 1 year of age (20 patients or 40.8%). Thirty two patients or 65.3% were admitted to wards and (17 patients or 34.7%) to ICU or PICU. Furthermore, among the virally co-infected patients LRTI was the most frequent reason for hospitalization (38 patients or 77.6%).

    Conclusion: Simultaneous testing of respiratory viruses by real-time PCR is a suitable tool for the detection and evaluating the role of viral co-infections in respiratory tract infections. The data of this study established a link between viral co-infections and an increase in disease severity.

    Widad Al-Nakib, FRCPath, FIDSA1, Sahar Essa, BSc, MSc, PhD.2, Haya Altawalah, BSc. MBBS. FRCPath3, Abdullah Owayed4, Mousa Khadadah5 and Nasser Behbehani5, (1)Microbiology Department, Kuwait University, Faculty Of Medicine, Kuwait, Kuwait, (2)Microbiology Department, Kuwait university, Faculty of Medicine, Kuwait, Kuwait, (3)Virology Unit, Ministry of health, Mubarak Hospital, KUWAIT, Kuwait, (4)Paediatrics, Kuwait University, Faculty of Medicine, Kuwait, Kuwait, (5)Medicine, Kuwait University, Faculty of Medicine, Kuwait, Kuwait

    Disclosures:

    W. Al-Nakib, None

    S. Essa, None

    H. Altawalah, None

    A. Owayed, None

    M. Khadadah, None

    N. Behbehani, None

    Findings in the abstracts are embargoed until 12:01 a.m. EDT, Oct. 8th with the exception of research findings presented at the IDWeek press conferences.

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