Viral co-infections in hospitalized patients with respiratory tract infections
Methods: The aim of this study is to investigate the role of viral co-infection in patients with respiratory tract infections (RTI) by using real time PCR techniques.
Results: In total, 934 hospitalised patients aged between 3 days and 80 years were screened over a three years period, from September 2010 to September 2013. Among the 351 patients diagnosed with viral infections, HRV was detected in 41.9%, FluA virus in 15.1% and RSV in 13.1%. Viral co-infection was detected in 49 patients (14%) with HRV being the most common virus associated with co-infection (26 patients or 7.4%), followed by AdV (14 patients or 4%) and HCoV-OC43 (12 patients or 3.4%). It was interesting to note that three patients had three viral co-infections. Among the 49 co-infected patients viral co-infections were common among those aged less than 1 year of age (20 patients or 40.8%). Thirty two patients or 65.3% were admitted to wards and (17 patients or 34.7%) to ICU or PICU. Furthermore, among the virally co-infected patients LRTI was the most frequent reason for hospitalization (38 patients or 77.6%).
Conclusion: Simultaneous testing of respiratory viruses by real-time PCR is a suitable tool for the detection and evaluating the role of viral co-infections in respiratory tract infections. The data of this study established a link between viral co-infections and an increase in disease severity.
H. Altawalah, None
A. Owayed, None
M. Khadadah, None
N. Behbehani, None