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1288
Rapid Dissemination of Universal Decolonization in Adult Intensive Care Units (ICUs) Reduces Healthcare-Associated (HA) Central Line Associated Bloodstream Infections (CLABSI) in over 100 Community Hospitals in a Single Healthcare System

Session: Oral Abstract Session: CLABSI: Surveillance and Prevention
Saturday, October 11, 2014: 9:30 AM
Room: The Pennsylvania Convention Center: 107-AB
Background: We conducted a 3 arm cluster randomized trial of three MRSA prevention strategies in 74 ICUs at 43 hospitals which demonstrated universal decolonization with chlorhexidine and mupirocin in adult ICUs resulted in a 44% reduction in risk of bloodstream infection due to all pathogens.(N Engl J Med 2013; 368:2255-2268) Implementing novel evidence based strategies across a large healthcare system presents challenges to scale to reach high compliance.

Methods: Starting in March 2013 HCA implemented universal decolonization in over 350 adult ICUs in over 160 acute care hospitals.  Planning and deployment tactics occurred thru central coordination with corporate infection prevention using intranet available toolkit resources, operational and process measures from a common EHR system and coaching calls.    Key stakeholders included leadership champions, healthcare providers, infection preventionists, pharmacists, IT&S and supply chain.   Primary analysis was reduction in HAI CLABSI using National Healthcare Safety Network (NHSN) surveillance definitions excluding the 74 ICU hospitals in the original trial. We defined the pre-implementation period as beginning in January, 2011 and ending in December 2012, and the post-implementation period as beginning in July 2013 and ending in February 2014.  The period of phase-in, between January and June 2013, was omitted from analysis.

We fit a Poisson Generalized Linear Mixed Model regression for the number of infections to assess differences between the pre- and post-implementation periods while accounting for hospital and unit level correlation.  We assessed the possibility of trend over time, and adjusted for seasonal effect, and number of beds in the unit.  The log total number of central lines was the offset.

Results: There was no evidence of trend over time in either the pre or post implementation period.  After implementation, the estimated rate of CLABSI decreased by 31% (p < .0001, 95% confidence interval [16%,40%]).  Adjusting for seasonality and number of beds minimally affected these results.

Conclusion: Universal decolonization of ICU patients was associated with significant decline in CLABSI across a large community hospital system confirming our original trial.  Rapid implementation is reproducible in a learning healthcare system.

Jason Hickok, RN, MBA1, Julia Moody, MS1, Ken Kleinman, ScD2, Taliser Avery, M.S.3, Susan S. Huang, MD, MPH, FIDSA4, Sara Bienvenu, MSN1, Jonathan Perlin, MD, PhD, MSHA, FACP, FACMI1, Richard Platt, MD, MS, FSHEA2 and Edward Septimus, MD, FIDSA, FSHEA1, (1)Clinical Services Group, HCA Inc, Nashville, TN, (2)Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, (3)Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, (4)Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, Irvine, CA

Disclosures:

J. Hickok, Sage Products: Conducting a clinical trial (ABATE) for which contributed product is being provided to participating hospitals, Contributed Product
Molnlycke: Conducting a clinical trial (ABATE) for which contributed product is being provided to participating hospitals, Contributed product
AHRQ, CDC NIH: Grant Investigator, Grant recipient

J. Moody, Sage Products: Conducting a clinical trial (ABATE) for which contributed product is being provided to participating hospitals, Contributed Product
Molnlycke: Conducting a clinical trial (ABATE) for which contributed product is being provided to participating hospitals, Contributed product
AHRQ, CDC, NIH: Grant Investigator, Grant recipient

K. Kleinman, Sage Products: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed Product
Molnlycke: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed product

T. Avery, Sage Products: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed Product
Molnlycke: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed product

S. S. Huang, Sage Products: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed Product
Molnlycke: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed product

S. Bienvenu, Sage Products: Conducting a clinical trial (ABATE) for which contributed product is being provided to participating hospitals, Contributed product
Molyncke: Conducting a clinical trial (ABATE) for which contributed product is being provided to participating hospitals, Contributed Product
AHRQ, CDC, NIH: Team member of Grant Investigator, Grant recipient

J. Perlin, Sage Products: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed Product
Molnlycke: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed product
AHRQ, CDC, NIH: Grant Investigator, Grant recipient

R. Platt, None

E. Septimus, sage and molnlyke: received product, provided product for ABATE study
AHRQ, CDC, NIH: Grant Investigator, Grant recipient

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