Program Schedule

Statin Use and Hospital-onset Clostridium difficile Infection;  A Case Control Study

Session: Poster Abstract Session: Clostridium difficile Infection: Epidemiology, Presentation, Treatment
Saturday, October 11, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
  • Statin use and CDI.pdf (217.2 kB)
  • Background: Hospital-onset Clostridium difficile infection (CDI) is the leading infectious cause of healthcare acquired infectious diarrhea. In addition to adding to morbidity and mortality in hospitalized patients, it is adding significant financial burden with estimated attributable costs of $436–$580 million in 2003. In this study we aim to evaluate association between statin use and risk of hospital-onset C. diffcile infection

    Methods: This matched case-control study was conducted in a 310-bed community hospital catering suburban population. Hospital-onset CDI cases were identified as patients developing diarrheal illness beyond 48 hours of hospital admission and tested positive for C. difficile on stool assay (enzymeimmune assay for toxin A and B or polymerase chain reaction for toxin producing gene) from Oct. 2005 through Sept.  2012. Controls (matched for age, gender, proton pump inhibitor (PPI) use, length of hospital stay and Elixhauser co-morbidity index, 2:1) were obtained from cohort of patients admitted to medical service during same period. Use of statin was reviewed during hospital stay and/or prior to admission. Two-tailed p-value of <0.05 was considered significant.

    Results: Total of 269 cases and 538 controls were included in study. Mean age, gender, PPI use, length of hospital stay and Elixhauser co-morbidity index were comparable amongst cases and controls. Statin use was not associated with hospital-onset CDI, chi-square 0.024, p=0.8762, p=3694. Relative risk was 0.91 (95% CI 0.73 to 1.22).

    Conclusion: Our study suggests that use of Statins doesn’t alter the risk of hospital-onset CDI infection.

    Ahmad Ramy Elashery, MD, Internal Medicine, Greater Baltimore Medical Center, Baltimore, MD


    A. R. Elashery, None

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