Statin Use and Hospital-onset Clostridium difficile Infection; A Case Control Study
Methods: This matched case-control study was conducted in a 310-bed community hospital catering suburban population. Hospital-onset CDI cases were identified as patients developing diarrheal illness beyond 48 hours of hospital admission and tested positive for C. difficile on stool assay (enzymeimmune assay for toxin A and B or polymerase chain reaction for toxin producing gene) from Oct. 2005 through Sept. 2012. Controls (matched for age, gender, proton pump inhibitor (PPI) use, length of hospital stay and Elixhauser co-morbidity index, 2:1) were obtained from cohort of patients admitted to medical service during same period. Use of statin was reviewed during hospital stay and/or prior to admission. Two-tailed p-value of <0.05 was considered significant.
Results: Total of 269 cases and 538 controls were included in study. Mean age, gender, PPI use, length of hospital stay and Elixhauser co-morbidity index were comparable amongst cases and controls. Statin use was not associated with hospital-onset CDI, chi-square 0.024, p=0.8762, p=3694. Relative risk was 0.91 (95% CI 0.73 to 1.22).
Conclusion: Our study suggests that use of Statins doesn’t alter the risk of hospital-onset CDI infection.
A. R. Elashery, None
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