Program Schedule

The Preventability of Ventilator-Associated Events:† The CDC Prevention Epicentersí Wake Up and Breathe Collaborative

Session: Oral Abstract Session: SHEA Featured Abstract
Friday, October 10, 2014: 4:30 PM
Room: The Pennsylvania Convention Center: Terrace Ballroom-I, II, III, IV

The Centers for Disease Control and Prevention replaced its ventilator-associated pneumonia definitions with ventilator ventilator-associated event (VAE) definitions in early 2013.  Little is known about preventing VAEs. We hypothesized that coordinated, daily spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs) might prevent VAEs by decreasing patients’ sedative and ventilator exposures.


We nested a multicenter quality improvement collaborative within a prospective study of VAE surveillance in 20 adult medical, surgical, medical-surgical, and cardiac intensive care units between November 2011 and May 2013. Twelve units joined the collaborative and implemented an opt-out protocol for nurses and respiratory therapists to initiate paired daily SATs and SBTs.  The 8 remaining units conducted surveillance alone. The collaborative included two in-person meetings, monthly written reports, conference calls, and data feedback. We evaluated temporal trends in VAE rates and other outcomes per episode of mechanical ventilation using generalized mixed effects regression models adjusted for unit, age, sex, reason for intubation, SOFA score, and comorbidity index.


We tracked 5,164 consecutive episodes of mechanical ventilation: 3,425 in collaborative units and 1,739 in surveillance-only units.  Within collaborative units, there were significant increases in SATs, SBTs, and the percentage of SBTs performed without sedation. Mean duration of mechanical ventilation decreased by 2.4 days (95% CI 1.7-3.1), ICU length-of-stay by 3.0 days (95% CI, 1.6-4.3), and hospital length-of-stay by 6.3 days (95% CI, 4.0-8.6). There were significant decreases in ventilator-associated conditions (OR 0.63, 95% CI 0.42-0.97) and infection-related ventilator-associated complications (OR 0.35, 95% CI 0.17-0.71) but not Possible or Probable Pneumonia (OR 0.51, 95% CI 0.19-1.3).  There was a significant increase in self-extubations (OR 2.1, 95% CI 1.1-3.9) but no change in re-intubations within 24 hours (OR 0.96, 95% CI 0.66-1.4).  Within surveillance-only units, there were no significant changes in SAT, SBT, or VAE rates.


Nurse and respiratory therapist led opt-out protocols for paired, daily SATs and SBTs were associated with significant reductions in length-of-stay and VAEs.

Michael Klompas, MD, MPH, FRCPC, FIDSA1, Deverick Anderson, MD, MPH2, William Trick, MD3, Hilary M. Babcock, MD, MPH4, Ronda Sinkowitz-Cochran, MPH5, E. Wesley Ely, MD, MPH6, John Jernigan, MD, MS7, Shelley S. Magill, MD, PhD5, Rosie D. Lyles, MD, MHA8, Caroline O' Neil, MPH9, Michele Balas, PhD, RN10, Michael V. Murphy, BA1, Christopher Cox, MD11, Ebbing Lautenbach, MD, MPH, MSCE12, Daniel J. Sexton, MD, FIDSA13, Victoria J. Fraser, MD, FIDSA, FSHEA4, Robert A. Weinstein, MD, FIDSA, FSHEA14 and Richard Platt, MD, MS, FSHEA1, (1)Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, (2)Duke University Medical Center, Durham, NC, (3)Stroger Medical Center, Chicago, IL, (4)Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, (5)Centers for Disease Control and Prevention, Atlanta, GA, (6)Vanderbilt University, Nashville, TN, (7)Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, (8)Stroger Hospital of Cook County, Chicago, IL, (9)Washington University, St. Louis, MO, (10)The Ohio State University, Columbus, OH, (11)Duke University, Durham, NC, (12)University of Pennsylvania School of Medicine, Philadelphia, PA, (13)Division of Infectious Diseases, Duke University Medical Center, Durham, NC, (14)Internal Medicine, Section of Infectious Diseases, Cook County Health and Hospitals System, Chicago, IL


M. Klompas, None

D. Anderson, None

W. Trick, None

H. M. Babcock, None

R. Sinkowitz-Cochran, None

E. W. Ely, Abbott: Speaker's Bureau, Speaker honorarium
Hospira: Speaker's Bureau, Speaker honorarium
Orion: Speaker's Bureau, Speaker honorarium

J. Jernigan, Sage Products: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed Product
Molnlycke: Conducting a clinical trial for which contributed product is being provided to participating hospitals, Contributed product

S. S. Magill, None

R. D. Lyles, None

C. O' Neil, None

M. Balas, None

M. V. Murphy, None

C. Cox, None

E. Lautenbach, None

D. J. Sexton, UpToDate: Editor, Royalties
National Football League: Consultant, Consulting fee and Educational grant
Cubist: Grant Investigator, Grant recipient
Johnson and Johnson: Consultant, Consulting fee

V. J. Fraser, None

R. A. Weinstein, None

R. Platt, None

See more of: SHEA Featured Abstract
See more of: Oral Abstract Session

Findings in the abstracts are embargoed until 12:01 a.m. EDT, Oct. 8th with the exception of research findings presented at the IDWeek press conferences.

Sponsoring Societies:

© 2014, All Rights Reserved.

Follow IDWeek