Genetic Polymorphisms and Risk of Infectious Wheezing in Pediatric Age
Methods: The study involved 119 otherwise healthy infants admitted to hospital for a first episode of infectious wheezing (74 of whom subsequently experienced recurrent episodes) and 119 age- and sex-matched subjects without any history of respiratory problem randomly selected during the study period. All of the study subjects were followed up for two years, and 47 single nucleotide polymorphisms (SNPs) in 33 candidate genes were genotyped on whole blood using an ABI PRISM 7900 HT Fast Real-time instrument.
Results: IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were associated with a significantly increased risk of developing infectious wheezing (p=0.02, p=0.03, p=0.05 and p=0.0018), whereas CTLA4-rs3087243AG and NFKBIB-rs3136641TT were associated with a significantly reduced risk (p=0.05 and p=0.04). IL8-rs4073AT, VEGFA-rs2146323AA and NFKBIA-rs2233419AG were associated with a significantly increased risk of developing recurrent wheezing (p=0.04, p=0.04 and p=0.03), whereas TLR3-rs3775291TC was associated with a significantly reduced risk (p=0.03). Interestingly, the study of gene-environment interactions showed that rhinovirus was significantly associated with recurrent wheezing in the presence of IL4Ra-rs1801275GG and G (odds ratio [OR] 6.03, 95% confidence interval [CI]: 1.21-30.10, p=0.03) and MAP3K1-rs702689AA (OR 4.09, 95% CI: 1.14-14.61, p=0.03).
Conclusion: This study shows a clear relationship between the risk of infectious wheezing and polymorphisms of some genes involved in the immune response. These findings may be useful for the early identification of children at the highest risk of developing recurrent infectious wheezing and possibly subsequent asthma.
C. Daleno, None
A. Scala, None
L. Terranova, None
C. Tagliabue, None
W. Peves Rios, None
C. Pelucchi, None
N. Principi, None
See more of: Oral Abstract Session