Program Schedule

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Changes in antibacterial resistance patterns in Staphylococcus aureus strains which are related to microbiologically confirmed nosocomial bacteraemia in a tertiary care educational hospital in Turkey: A perspective through 2001-2013

Session: Poster Abstract Session: MRSA and VRE
Thursday, October 9, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC

Background: In this study it was aimed to evaluate the resistance patterns of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001-2013 retrospectively
Methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (Sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB. Data of antibacterial resistance and hospital admission dates were extracted from hospital patient record database. Double or more isolates during each episode were counted as one episode. Blood cultures were performed on Bact/Alert (bioMerieux, Durham, NC). Bacterial identifications were performed by automated API (bioMerieux, Durham, NC). Oxoid antibiotic dics (England) were used to test antibacterial susceptibility by disc diffusion method following the recommendations of CLSI. Results were interpreted as described by CLSI. Resistance patterns in the 2001-2003 and 2011-2013 periods were compared by Chi-square test.
Results: Oxacillin resistance in 2001 was 73.8% and %36.2 in 2013 Table). When 2001-2003 and 2011-2013 periods were compared, resistance to oxacillin, levofloxacin, gentamicin, erythromycin and clindamycin decreased significantly (p<0.05) (Table 1). No glycopeptide and linezolid resistant strain was isolated  during the study period.

Conclusion: There was a steady decrease in the overall S. aureus MCNB as well as methicillin resistance rates except 2008-11 which require further investigation. This steady decrease in the resistance rates after the 2003 budget application (which required prior approval of infectious diseases specialist for all extended spectrum antibiotics) and which is probably due to it, suggests that the application may also be useful in decreasing the antimicrobial resistance in at least S. aureus

 Table: Resistance rates between 2000 and 2013.

Oguz Sipahi1, Serhat Uysal1, Sohret Aydemir2, Husnu Pullukcu1, Meltem Tasbakan1, Alper Tunger1, Feriha Cilli1, Tansu Yamazhan1, Bilgin Arda1, Hilal Sipahi3 and Sercan Ulusoy1, (1)Ege University Faculty of Medicine, Izmir, Turkey, (2)Microbiology, Ege University, Izmir, Turkey, (3)Bornova Public Health Center, Izmir, Turkey

Disclosures:

O. Sipahi, None

S. Uysal, None

S. Aydemir, None

H. Pullukcu, None

M. Tasbakan, None

A. Tunger, None

F. Cilli, None

T. Yamazhan, None

B. Arda, None

H. Sipahi, None

S. Ulusoy, None

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