Program Schedule

1347
Evaluation of Circulating sCD200 (OX-2), High Sensitive C-reactive Protein and Sedimentation Rate in Diabetic Foot Patients

Session: Poster Abstract Session: Biomarkers of Immune Responses
Saturday, October 11, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
Background: CD200 (OX-2) is a novel immune-effective molecule, both cell membrane bound and also existing in a soluble form in serum (sCD200), which acts to regulate inflammatory and acquired immune responses. Recently, our study group showed that sCD200 in serum and blister fluid in a patient with bullous pemphigoid and anti-IgE therapy impact on those levels.  We therefore planned this study to evaluate the serum sCD200 levels of diabetic foot and compare it with that of healthy controls. We also analyzed the association between the serum sCD200 levels and the clinical severity of the disease in diabetic foot patients.

Methods: The study was performed with 32 diabetic foot infection patients and 25 healthy control patients. sCD200 concentrations were quantified by using ELISA kit.

Results: We found that sCD200 levels in diabetic foot patients were higher than control group (124.79±4.22 vs 21.57±1.11 [mean±SEM], p<0.0001). However there is no correlation between sCD200 levels and the Hba1c levels, blood glucose levels (pre/postprandial) and BMI these markers. The hs-CRP levels and sedimentation rates were higher in patient group (p<0.0001, p<0.005 and p<0.0001 respectively).

Conclusion: To the best of our knowledge, this is the first study to assess serum sCD200 in diabetic patients with the late complication of diabetic footinfection.We investigated evidence for possible correlations between serum CRP levels, hs-CRP, and HbA1c, pre-prandial glucose levels BMI, WGS, and sedimentation rate. The sCD200 levels did not correlate with any of these markers.

Nefise Oztoprak1, Arzu Didem Yalcin2, Gizem Esra Genc3, Filiz Kizilates1 and Saadet Gumuslu3, (1)Infectious Diseases and Clinical Microbiology, Antalya Education and Research Hospital, Antalya, Turkey, (2)Allergy and Immunology, Genomics Research Center, Academia Sinica, Taipei, Taiwan, (3)Medical Biochemistry, Akdeniz University Medical Faculty, Antalya, Turkey

Disclosures:

N. Oztoprak, None

A. D. Yalcin, None

G. E. Genc, None

F. Kizilates, None

S. Gumuslu, None

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