Program Schedule

Impact of OxyCide™ Use on Environmental Contamination and Infection Rates Compared To Standard Cleaning Practice

Session: Poster Abstract Session: Cleaning and Disinfection in Healthcare Settings
Saturday, October 11, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
  • OXY finalsh.pdf (1.6 MB)
  • Background:

    The aims of this study were to compare the standard cleaning practice to cleaning using OxyCide™, a novel, sporicidal, one-step disinfectant concentrate on environmental contamination and hospital-acquired infections (HAIs).   


    A cross-over study was conducted using 1 medical-surgical and 1 intensive care unit. In the intervention group, OxyCidewas used for routine cleaning of all patient rooms.  In the control group, standard cleaning was conducted using Virex II 256- quaternary ammonium compound and Dispatch for C. difficile rooms; and Virex II alone for other rooms. The study period was 13 months. Using moist cotton swabs, qualitative environmental cultures were collected after terminal cleaning from selected rooms of discharged patients with A. baumannii or C. difficile; and quantitative samples were collected from occupied rooms.  Standard laboratory procedures were used.  HAIs were tracked throughout the study period.


    A total of 4,105 patients were cared for on study units during the study period, accounting for 20,932 patient days.  After terminal cleaning, 747 samples were collected from 69 rooms (27 C. difficile and 42 A. baumannii). There was no growth from 331 swabs collected in the control group and 2/416 swabs (0.5%) from the intervention group grew (1/270 for A. baumannii and1/146 for C. difficile).  

    216 swabs were collected from high touch objects in 36 occupied patient rooms (18 in each group). 18/108 (17%) samples from the control group grew, as did 20/108 (18.5%) from the intervention group (p=0.85).

    There were a total of 122 unit-acquired infections, 24 device-related infections, 15 unique patients with A. baumannii and 25 with C. difficile.  The rate of HAI was 6.6 in the control arm and 4.8/1000 patient days in the intervention arm (p=0.09); of device-related infection was 1.6 and 0.6/1000 patient days, respectively (p=0.04); of A. baumannii was 0.7 and 0.7/1000 patient days respectively (p=0.98); and of C. difficile, was 1.0 and 1.4/1000 patient days, respectively (p=0.36). 


    Use of OxyCide™ was associated with decreased device-related hospital infections when compared to standard cleaning with quaternary ammonium compound +/- bleach.  Recovery of environmental pathogens was low in both study arms.

    Samran Haider, MD1, Judy Moshos, MT (ASCP), CIC2, Tim Burger3, Philip Carling, MD4, Paul Lephart, PhD5, Paul Kilgore, MD, MPH6, Debbie Decamillo, RN2 and Keith Kaye, MD, MPH, FIDSA, FSHEA7, (1)Detroit Medical Center / Wayne State University, Detroit, MI, (2)Detroit Medical Center/Wayne State University, Detroit, MI, (3)LAB-Microbiology Core, DMC University Laboratories, Detroit, MI, (4)Medicine, Boston University School of Medicine, Boston, MA, (5)Detroit Medical Center University Laboratories, Detroit, MI, (6)Pharmacy Practice, Wayne State University, Detroit, MI, (7)Wayne State University, Detroit, MI


    S. Haider, None

    J. Moshos, None

    T. Burger, None

    P. Carling, None

    P. Lephart, None

    P. Kilgore, None

    D. Decamillo, None

    K. Kaye, Ecolab: Grant Investigator, Grant recipient

    Findings in the abstracts are embargoed until 12:01 a.m. EDT, Oct. 8th with the exception of research findings presented at the IDWeek press conferences.

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