A Prospective Analysis of the Clinical Spectrum of Different Subtypes Human Enterovirus and Human Parechovirus
Enterovirus (EV) and Human Parechoviruses (HPeV) are a major cause of aseptic meningitis in children. There a 4 species (A-D) human EV and 2 species parechoviruses (HPeV and Ljungan virus). The aim of this study is to prospectively describe the clinical spectrum of different EV and HPeV subtypes in children.
This study is part of a multicenter prospective study, involving children 0-16 years visiting three major general hospitals in the Netherlands. Children with clinical suspicion of an EV or HPeV infection were included and those with other cause of illness are excluded.
From 285 included patients, 140 (39%) and 44 (12%) had an EV and HPeV infection, respectively. There were no significant differences in baseline characteristics. 54% of the EV infected children had a meningitis and 15% a gastro-enteritis. EV subtype A (EV-A) was found in 9 children and EV-B in 109, in 22 the subtype was unknown. Children with EV-B infection had significant more often a meningitis than children with an EV-A infection (60% versus 33%, p=0.007). HPeV subtype 3 (HPeV-3) was most detected in 24 (55%) children, HPeV-1 in 6 (14%), HPeV-4 in 2 and HPeV-6 in 1, in 11 the subtype was unknown. Children with a HPeV-1 infection had more often a gastro-enteritis than children with a HPeV-3 infection (83% versus 4%, p<0.01).
EV infection is more associated with meningitis than HPeV infection, especially EV-B. HPeV infection is more associated with a gastro-enteritis than EV infection, especially HPeV-1.
M. Van Furth, None
R. De Moor, None
J. Rossen, None
E. Veldkamp, None