Effect of chlorhexidine bathing and other infection control practices on the Benefits of Universal Glove and Gown (BUGG) Trial: A subgroup-analysis
Background : Multiple interventions exist to limit transmission of methicillin-resistant Staphylococcus aureus (MRSA). The effect of combining different interventions is not known.
Methods: We conducted a subgroup analysis of the Benefits of Universal Glove and Gown (BUGG) trial to examine the effect of universal gloving and gowning while using other infection control interventions.
Results: Over 20 ICUs and 26,180 patient admissions, the reduction in MRSA transmission observed in BUGG tended to be greater in units also using chlorhexidine bathing (rate difference -1.20, 95% CI -5.02 to 2.63, p-value=0.18) and was significantly greater in units switching from active surveillance culturing for MRSA (rate difference -8.16, 95% CI -16.42 to 0.01, p-value=0.05). We found universal glove and gown use worked equally well in academic and non-academic ICUs (p=0.15).
Conclusion: The reduction in MRSA observed with the universal glove and gown intervention was persistent in units also using chlorhexidine bathing and in academic and non-academic hospitals. Universal glove and gown use appeared to work as well or better in ICUs adopting universal glove and gown after being on active surveillance culturing.
Figure 1: Frequency of MRSA acquisition in patients during baseline and study periods representing the effect of universal glove and gown on patients in intensive care units that did or did not use chlorhexidine bathing.
M. Shardell, None
C. Sulis, None
D. H. Kett, None
J. E. Bowling, None
B. Belton, None
A. D. Harris, None