Program Schedule

Skin lesions in febrile neutropenic patients

Session: Poster Abstract Session: Transplant Infectious Diseases
Thursday, October 9, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
  • Skin lesions.pdf (323.5 kB)
  • Background: Rashes in febrile neutropenic patients present an important problem in differential diagnosis for their physicians. In these patients, rashes may be the first and only evidence of a serious and life-threatening infection. In this study, we aimed to retrospectively report the etiology of skin lesions in febrile neutropenic patients with hematologic malignancies.

    Methods: In our study, hospitalized febrile neutropenic patients with hematologic malignancy, aplastic anemia, or bone marrow transplantation were included. Patient files were screened retrospectively and patients with skin lesions during febrile neutropenic episodes were selected. Patients with febrile neutropenia were initiated an antipseudomonal beta-lactam therapy according to IDSA guidelines. Skin lesions of these patients during febrile neutropenic episode, consulted and evaluated with infectious disease and dermatology specialists

    Results: A total of 50 patients were included in our study. Twenty six (52%) of the patients were male and the average age was 45.8 (± 15), respectively. The most common underlying disease was acute myeloid leukemia with 29 (48%) patients. The most frequently observed type of lesion was maculopapular eruption (40%) whilst it was followed by erythematous necrotic nodule (18%). The most common cause of skin lesions were infections and  drug eruptions with 26 (52%) and 16 (32%) patients, respectively. Ecthyma gangrenosum in 8 patients, skin involvement of oppurtunistic fungal infections in 7 patients and herpes labialis in 5 patients were most common causes of skin lesions in infection group. In 16 (32%) patients the skin lesions were found to be related to drugs; piperacillin/tazobactam, co-trimaxazol and etoposid were the most common cause of drug related skin lesions. Of the patients, 6 patients died during or soon after the development of skin lesions and in 5 of 6 patients, the skin lesions were found to be related with infectious causes. 

    Conclusion: Infections were found to be the most common cause of skin lesions in febrile neutropenic patients.

    Mucahit Yemisen1, Asli Vatan1, Ilker Balkan1, Ayse Salihoglu2, Tugrul Elverdi2, Emre Eskazan2, Bilgul Mete1, M.Cem Ar2, Seniz Ongoren2, Zafer Baslar2, Resat Ozaras1, Nese Saltoglu1, Recep Ozturk1, Teoman Soysal2 and Fehmi Tabak1, (1)Infectious Diseases, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey, (2)Internal Medicine, Hematology Section, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey


    M. Yemisen, None

    A. Vatan, None

    I. Balkan, None

    A. Salihoglu, None

    T. Elverdi, None

    E. Eskazan, None

    B. Mete, None

    M. C. Ar, None

    S. Ongoren, None

    Z. Baslar, None

    R. Ozaras, None

    N. Saltoglu, None

    R. Ozturk, None

    T. Soysal, None

    F. Tabak, None

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