The Comparison of in-vitro Activity of Daptomycin with Vancomycin and Teicoplanin against Methicillin-Resistant Staphylococcus aureus Strains Isolated from Bloodstream Infections
Methods: The identification of the MRSA isolates was based on conventional microbiological methods and an additional automated identification system (VITEK®2, bioMerieux, France). A total of 200 MRSA clinical isolates were included in the study. Daptomycin, vancomycin, and teicoplanin susceptibility were investigated by E-test (AB bioMerieux, Sweden). E-test was performed according to the instructions of the manufacturer. Susceptibilities of the strains to daptomycin, vancomycin, and teicoplanin were performed using the E-test according to the recommendations of CLSI 2013/EUCAST 2014 and the manufacturer.
Results: The MIC ranges were 0.25-1 µg/ml for daptomycin, 1.5-6 µg/ml for vancomycin, and 2-16 µg/ml for teicoplanin. Daptomycin was found to exhibite a good activity.
Conclusion: According to MIC values, daptomycin seems 6 times more effective than vancomycin and 8-16 times more effective than teicoplanin. With having the lowest MIC values, daptomycin may represent a therapeutic option for the infections caused by MRSA.
N. Demirturk, None