Program Schedule

1388
Eradication of Medically Important Multidrug Resistant Bacteria and Fungi Using PurpleSun Inc. Multivector UV Technology

Session: Poster Abstract Session: Cleaning and Disinfection in Healthcare Settings
Saturday, October 11, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
Background: Hospital associated infections are important causes of morbidity and mortality that cost the nation billions of dollars per year. Although major advances in infection control practice have reduced the frequency of hospital-associated infections, thousands of lives continue to be lost. New strategies and technologies are clearly needed in order to reduce the incidence of these infections. We tested the modular Ultraviolet-C light (UVC) disinfection unit from PurpleSun Inc. The unit can be used in wide areas, as well as configured for disinfecting critical objects such as patient beds, operating tables, and med-carts. The modularity allows for deployment anywhere at anytime, without the inconvenience of leaving the immediate patient room or healthcare work environment.

Methods: Three isolates of each following resistant bacterial pathogens and pathogenic fungi were used in the study: methicillin-resistant Staphylococcus aureus  (MRSA), vancomycin-resistant Enterococcus faecium (VRE), ESBL Escherichia coli (EC), carbapenemase-resistant Klebsiella pneumoniae (KPC), multidrug-resistant Pseudomonas aeruginosa (PA), Acinetobacter baumannii (AB), Clostridium difficile (CD), Candida albicans (CA), C. glabrata (CG), C. parapsilosis (CP), C. krusei (CK), Aspergillus fumigatus (AF), Fusarium solani (FS), and Scedosporium apiospermum (SA). Plates containing two different sizes of inoculum 1-5 ´ 103-104 or 1-5 ´ 101-102were exposed to UV energy at different times (s) and locations in the UV field, according to the design of the study.

Results: Full clearance of the organism from the plates was achieved at 15 s of exposer for MRSA and PA. Clearance of VRE, EC, CG, CP, CK, FS, and SA was achieved after 30 s of exposure. KPC, AB, CA, and CD demonstrated no growth after 60 s of exposure to the UVC. The longest time, 120 s, was required to clear AF. The rate of clearance of organisms from the plates didn’t depend on inoculum size.

Conclusion: The study demonstrated that UVC disinfection unit eradicates tested resistant bacteria and pathogenic fungi effectively and rapidly. Inoculum size did not affect rate of kill of tested organisms. This study provides foundation for the future testing of the UVC disinfection unit in the clinical environment.

Vidmantas Petraitis, MD1, Ruta Petraitiene, MD1, Audrey N. Schuetz, MD1, Kathleen Kennedy-Norris, Ph.D2, John H. Powers, Ph.D3, Shannon L. Dalton, Ph.D3, Egle Petraityte, BS1, Kaiser a. Hussain, MD1, Myint L. Kyaw, MD1 and Thomas J. Walsh, MD1, (1)Weill Cornell Medical College of Cornell University, New York, NY, (2)Baltimore City Community College, Baltimore, MD, (3)Baltimore BioWorks, Inc., Baltimore, MD

Disclosures:

V. Petraitis, None

R. Petraitiene, None

A. N. Schuetz, None

K. Kennedy-Norris, None

J. H. Powers, None

S. L. Dalton, None

E. Petraityte, None

K. A. Hussain, None

M. L. Kyaw, None

T. J. Walsh, None

Findings in the abstracts are embargoed until 12:01 a.m. EDT, Oct. 8th with the exception of research findings presented at the IDWeek press conferences.

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