The Impact of Influenza Vaccination in Patients with Cancer on Subsequent Disease during the 2013-2014 Influenza Season
Methods: A phone survey for cancer patients with laboratory confirmed influenza (LCI) was carried out during the influenza season 2013-2014 to determine impact on clinical outcomes including hospitalization, intensive care unit stay and death.
Results: A total of 105 out 139 adults with LCI participated in the phone survey at a rate of 77%. A total of 47 (45%) were vaccinated and 58 (55%) were not and their baseline characteristics were similar. Median age was 57 y.o. (21 - 88) while 61% were male and 59% were Caucasians. Most common underlying conditions were hematopoietic cell transplant (51%), solid tumors (19%) and leukemia (14%). On multivariable analysis, patients who progressed to pneumonia were more likely to be neutropenic, were older, had delay in diagnosis from symptoms onset, and did not receive oseltamivir at upper respiratory tract infection stage (all p<0.05). Vaccination status had no significant impact on progression to pneumonia or mortality.
Conclusion: In our cohort, almost half of the patients who had influenza were vaccinated. Interestingly, influenza vaccination during the current season did not have an impact on the severity of illness including incidence of pneumonia, hospitalization or mortality rates in our cancer patients. Although not determined in this study, vaccination may have protected our cancer patients from acquiring influenza.
D. P. Shah, None
L. Nesher, None
S. S. Ghantoji, None
L. Michailidis, None
L. Marsh, None
R. F. Chemaly, None