Clinical Prognostic factors to evaluate outcomes in Adult Patients with acute encephalitis
Methods: This was a retrospective study done at Memorial Hermann Hospital in Houston, Texas and Tulane Medical Center/Charity hospital in New Orleans, Louisiana from 1999-2013. We used bivariate and logistic regression analysis to evaluate baseline variables in patients with encephalitis to identify predictors of an adverse clinical outcomes (ACO) as defined as a Glasgow Outcome Scale of 1-4.
Results: Our evaluation included 143 patients. 65 patients (43%) required intensive care unit admission. The median age was 49 years. 77 were male (53%). 37 (25%) had confirmed viral encephalitis. 43 (30%) had an altered immune status. An adverse clinical outcome was found in 42% of the patients. ICU admission (p=0.041), Glasgow coma scale (GCS) <8 (p=0.017) and age > 60 years (p=0.04) were associated with an ACO on bivariate analyses. On logistic regression analysis, Age > than 60 (Odds ratio [OR] 4.114, 95% Confidence Interval [CI] 1.554-10,888), and a GCS< 8 (Odds ratio [OR] 5.501 95% Confidence Interval [CI] 1.702-17.785) were independently associated with an ACO.
Conclusion: Prognostic factors predicting a poor outcomes in patients with acute encephalitis include age >60 years and a Glasgow coma scale <8.
R. Hasbun, None
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