Program Schedule

Clinical Prognostic factors to evaluate outcomes in Adult Patients with acute encephalitis

Session: Poster Abstract Session: CNS Infections: Diagnostic Tools and Outcome Predictors
Friday, October 10, 2014
Room: The Pennsylvania Convention Center: IDExpo Hall BC
Background: Encephalitis continues to be a significant cause of morbidity and mortality, there are few studies assessing prognostic factors in patients with acute encephalitis. An objective was to evaluate predictors of outcomes at hospital discharge for adult patients with acute encephalitis after inpatient evaluation.

Methods: This was a retrospective study done at Memorial Hermann Hospital in Houston, Texas and Tulane Medical Center/Charity hospital in New Orleans, Louisiana from 1999-2013. We used bivariate and logistic regression analysis to evaluate baseline variables in patients with encephalitis to identify predictors of an adverse clinical outcomes (ACO) as defined as a Glasgow Outcome Scale of 1-4.

Results: Our evaluation included 143 patients. 65 patients (43%) required intensive care unit admission. The median age was 49 years. 77 were male (53%). 37 (25%) had confirmed viral encephalitis. 43 (30%) had an altered immune status. An adverse clinical outcome  was found in 42% of the patients. ICU admission (p=0.041), Glasgow coma scale (GCS) <8 (p=0.017) and age > 60 years (p=0.04) were associated with an ACO on bivariate analyses. On logistic regression analysis, Age > than 60 (Odds ratio [OR] 4.114, 95% Confidence Interval [CI] 1.554-10,888), and a GCS< 8   (Odds ratio [OR] 5.501 95% Confidence Interval [CI] 1.702-17.785) were independently associated with an ACO.

Conclusion: Prognostic factors predicting a poor outcomes in patients with acute encephalitis include age >60 years and a Glasgow coma scale <8.

Rodrigo Lopez, MD, Internal Medicine, University of Texas at Houston, Houston, TX, Lucrecia Salazar, MD, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX and Rodrigo Hasbun, MD, MPH, The University of Texas Health Science Center at Houston, Houston, TX


R. Lopez, None

L. Salazar, None

R. Hasbun, None

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