Methods: We conducted a prospective, single-center, case-control study between 12/01/2001 and 05/31/2006. Case patients were hospitalized with total hip or knee PJI. Control subjects underwent a THA or TKA and were hospitalized during the same period on the same orthopedic floor without a PJI. Data regarding demographic features and potential risk factors were collected. The outcome measure was the odds ratio (OR) of PJI after GU procedures performed within 2 years of admission.
Results: A total of 339 case patients and 339 control subjects were enrolled in the study. Of these, 52 cases (15%) and 55 controls (16%) had undergone a GU procedure in the preceding 2 years. There was no increased risk of PJI for patients undergoing a GU procedure with or without antibiotic prophylaxis [adjusted OR (aOR), 1.0; 95% confidence interval [CI], 0.2–4.5, p- value 0.95] and [aOR, 1.0; 95% CI 0.6-1.7, p- value 0.99] respectively. Results were similar in a subset of patients with a joint age less than 6 months, less than 1 year or greater than 1 year.
Conclusion: GU procedures were not risk factors for subsequent PJI. The use of antibiotic prophylaxis prior to GU procedures did not decrease the risk of subsequent PJI in our study.
A. D. Hanssen, None
D. Lightner, None
W. Wilson, None
J. Steckelberg, None
L. Baddour, None
W. Harmsen, None
J. Mandrekar, None
E. F. Berbari, None
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