1547. Genitourinary Procedures as Risk Factors for Prosthetic Hip or Knee Infection: A Hospital-Based Prospective Case-Control Study
Session: Poster Abstract Session: Clinical Infectious Diseases: Prosthetic Joint Infections
Saturday, October 10, 2015
Room: Poster Hall
Background: There are no prospective data defining the risk of prosthetic joint infection (PJI) as a complication of routine genitourinary (GU) procedures in patients with total hip (THA) or knee arthroplasty (TKA), or the impact of antibiotic prophylaxis administered prior to these procedures. 

Methods: We conducted a prospective, single-center, case-control study between 12/01/2001 and 05/31/2006. Case patients were hospitalized with total hip or knee PJI. Control subjects underwent a THA or TKA and were hospitalized during the same period on the same orthopedic floor without a PJI. Data regarding demographic features and potential risk factors were collected. The outcome measure was the odds ratio (OR) of PJI after GU procedures performed within 2 years of admission. 

Results: A total of 339 case patients and 339 control subjects were enrolled in the study. Of these, 52 cases (15%) and 55 controls (16%) had undergone a GU procedure in the preceding 2 years. There was no increased risk of PJI for patients undergoing a GU procedure with or without antibiotic prophylaxis [adjusted OR (aOR), 1.0; 95% confidence interval [CI], 0.2–4.5, p- value 0.95] and [aOR, 1.0; 95% CI 0.6-1.7, p- value 0.99] respectively. Results were similar in a subset of patients with a joint age less than 6 months, less than 1 year or greater than 1 year.

Conclusion: GU procedures were not risk factors for subsequent PJI. The use of antibiotic prophylaxis prior to GU procedures did not decrease the risk of subsequent PJI in our study.

Arjun Gupta, MD1, D Osmon, MD2, Arlen D. Hanssen, MD3, Deborah Lightner, MD4, Walter Wilson, MD, FIDSA5, James Steckelberg, MD, FIDSA6, Larry Baddour, MD, FIDSA7, William Harmsen, MS5, Jayawant Mandrekar, PhD8 and Elie F. Berbari, MD, FIDSA2, (1)University of Texas Southwestern Medical Center, Dallas, TX, (2)Mayo Clinic, Rochester, TX, (3)Orthopedics, Mayo Clinic, Rochester, MN, (4)Mayo clinic, Dallas, TX, (5)Mayo Clinic, Rochester, MN, (6)Infectious Diseases, Mayo Clinic, Rochester, MN, (7)Infectious Disease, Mayo Clinic, College of Medicine, Rochester, MN, (8)Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN


A. Gupta, None

D. Osmon, None

A. D. Hanssen, None

D. Lightner, None

W. Wilson, None

J. Steckelberg, None

L. Baddour, None

W. Harmsen, None

J. Mandrekar, None

E. F. Berbari, None

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