Methods: A retrospective, descriptive study of Fusarium spp infections in a specialized pediatric intensive care unit from January 2006 to March 2015
Results: A total of 15 patients developed Fusarium spp infections. Median age of patients was 48 months (interquartile range, 12-108 months) and the affected burn surface was 45% (interquartile range, 30-60%). Twelve patients (80%) had a full thickness burn.
The median time lapse between admission and fungal infection was 11 days (interquartile range, 4-24 days). The most frequent isolation site was the burn wound in 14 patients (93%) and bone in 1 patient (7%). In 13 patients (87%) bacterial infections were also found. Amphotericin B was the drug of choice followed by voriconazole. Median time of complete treatment was 23 days (interquartile range: 17-35 days). No drug-related adverse effects were reported. The combination of medical monotherapy with voriconazole or amphotericin B and surgery with removal of focal lesions was effective in all cases. None of the patients died of fungal-infection- related causes
Conclusion: Fusarium spp is an uncommon pathogen in severely burned patients. The combination of medical monotherapy with voriconazole or amphotericin B and surgery was effective in such cases. None of the patients died.
M. Villasboas, None
F. Quarracino, None
V. Alvarez, None
G. Berberian, None
N. Sberna, None
C. Sarkis, None
P. Santos, None