929. The role of Clostridium difficile infection in infancy as a risk factor of childhood atopy
Session: Poster Abstract Session: Clostridium difficile Infections: Epidemiology and Diagnostics
Friday, October 9, 2015
Room: Poster Hall
Background: Although gut microbiota can affect several diseases through immune modulatory mechanisms, the exact role of each microbe, especially Clostridium difficile, and the relationship between microbiota colonization at different ages and allergic diseases are not well known yet.

Methods: In infants aged 1 to 12 months with more than 2 weeks of bowel habit change in spite of milk protein restriction, Clostridium difficile infection (CDI) was identified with stool culture. Various associated clinical data were collected through reviewing medical records. After at least two years of follow-up, history of atopic conditions at early childhood was collected through medical records and parent-reported questionnaires. After dividing into two groups according to the presence of CDI, the risk of atopy development at childhood was identified with logistic regression analysis.

Results: A total of 65 patients were included, and 22 (33.8%) were diagnosed with CDI. The mean age at collection of fecal sample was 5.55±2.91 months, and 33 (50.8%) were male. Mode of delivery, gestational age, birth weight, maternal age at birth, birth order, duration of breast feeding, history of NICU admission and parental history of atopy were not different between two groups. Risk of developing at least one atopic condition was higher in CDI present group after adjusting for other variables (aOR=5.61; 95% CI 1.52-20.74, p=0.01). Food allergy was more prevalent in CDI present group (p=0.035). Infants with CDI were at higher risk of developing asthma (aOR=3.03; 95% CI 0.48-19.14), allergic rhinitis (aOR=4.42; 95% CI 0.63-31.25), and atopic dermatitis (aOR=5.93; 95% CI 0.63-55.28) without significance.

Conclusion: Colonization by C difficile in infancy increased the risk of atopic diseases in early childhood. CDI in infancy may affect the intestinal microbial circumstances through the change of immune response.

Eell Ryoo, M.D.1, Yunna Gong, Medical student2 and Hann Tchah, M.D.1, (1)Pediatrics, Gachon University, Gil Hospital, Incheon, South Korea, (2)Graduate school of Medicine, Gachon University, Incheon, South Korea

Disclosures:

E. Ryoo, None

Y. Gong, None

H. Tchah, None

Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.