524. Epidemiology, Seasonality and Coinfections of Community Respiratory Viral Infections at UMASS Memorial Medical Center between 2010 and 2013
Session: Poster Abstract Session: Respiratory Infections: Viral (non Influenza)
Thursday, October 8, 2015
Room: Poster Hall
  • Edited Poster Aline 091115.pdf (788.1 kB)
  • Background: Our knowledge of community Respiratory viruses (CRV) infections has predominantly come from studies of individual viruses in immunocompromised patients, children, and elderly.  The introduction of multiplex nucleic acid amplification tests (MNAAT) assay for multiple agents concurrently allows for new opportunities to study these viruses.  We have sought to further define the epidemiology of CRVs through a review of infections at a Massachusetts tertiary care center over a span of 4 years.   Methods: A retrospective cohort study was conducted on all patients tested between 2010 and 2013 for CRVs by rapid influenza and respiratory syncytical virus (RSV) antigen testing as well as an MNAAT for 12 CRVs.  Results: 8239 specimens were tested between January 2010 and December 2013, with 51.6 % found to have at least one respiratory virus. Among the tested patients, 60 % were adults (≥18) and 52 % were male. Among the patients with positive results, 43% were adults vs 57% children, 53 % were male, 75 % inpatient vs 25 % outpatient, and 86 % immunocompetent vs 14 % immunocompromised ( HIV or malignancies). Pronounced seasonal variation was found with influenza viruses, RSV, and human metapneumovirus, and less with the other CRVs. Rhinovirus was the most frequent virus isolated followed by RSV and influenza A. Influenza A was more common in adults, while Rhinovirus and RSV more in children. Rhinovirus was the most common virus in immunocompromised patients. We identified significant differences in the frequency of infection by gender for several of the CRVs. Influenza A was more common in women (p<0.001) and parainfluenza 1, rhinovirus and adenovirus in men (p <0.05). 377 patients were infected with more than one virus; most prevalent coinfections were seen with rhinovirus, RSV and adenovirus and the least with influenza A and B. Conclusion: This is the largest study to date addressing the epidemiology of CRVs, and confirms prior observations on variations in the seasonality and age distribution seen with these pathogens. In addition, there appears to be relatively significant differences in the frequency of infection by gender for select CRVs, an observation which requires further investigation
    Aline Azar, MD, Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA, Melissa Mcguirl, student, Department of Mathematics and Computer Science, College of the Holy Cross, Worcester, MA, Shannon Stock, PhD, Department of mathematics and Computer Science, College of the Holy cross, worcester, MA, Julien Fahed, MD, Internal Medicine, UMASS, worcester, MA, Apurva Akkad, BS, University of Massachussetts medical school, worcester, MA, Shu Yang, AB, University of Massachussetts Medical School, worcester, MA, Tara Bouton, MD, MPH&TM, Internal Medicine, University of Massachusetts, Worcester, MA and Richard Ellison III, MD, FIDSA, FSHEA, Infectious Disease and Immunology, University of Massachusetts Medical School, worcester, MA


    A. Azar, None

    M. Mcguirl, None

    S. Stock, None

    J. Fahed, None

    A. Akkad, None

    S. Yang, None

    T. Bouton, None

    R. Ellison III, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.