267. Trends in the distribution and antimicrobial susceptibility of causative pathogens of device associated infection in Korean intensive care units from 2006 to 2013: results from the Korean Nosocomial Infections Surveillance (KONIS) system
Session: Poster Abstract Session: HAI: Device Associated Infections
Thursday, October 8, 2015
Room: Poster Hall
Posters
  • ID week poster.pdf (490.1 kB)
  • Background: The knowledge on the distribution of causative pathogens of healthcare-associated infections (HAIs) and their antimicrobial susceptibilities is crucial for developing appropriate strategies for prevention and treatment of HAIs.

    Methods: Data from the Korean Nosocomial Infections Surveillance (KONIS) system were analyzed. The KONIS system was established in 2006, and has performed prospective surveillance for three major device associated infections (DAIs) including ventilator-associated pneumonia (VAP), central line-associated bloodstream infection (CLABSI), and catheter-associated urinary tract infection (CAUTI) in ICU. We evaluated yearly trends of the frequencies of the causative pathogens and the rate of antimicrobial resistances.

    Results: For CLABSI and VAP, the frequency of Gram(-) bacteria gradually increased (for CLABSI from 24.6% in 2006 to 32.6% in 2013, for VAP from 52.8% in 2006 to 73.5% in 2013). In contrast, the frequency of Gram(+) bacteria decreased (for CLABSI from 58.6% in 2006 to 49.2% in 2013, for VAP from 44.3% in 2006 to 23.8% in 2013, P<0.001). The most frequent pathogen for CLABSI was Staphylococcus aureus during 7 years. For VAP, S. aureus was the most frequent pathogen from 2006 to 2009, however, Acinetobacter baumannii emerged as the most frequent pathogen for VAP since 2010. Candida albicans was the most frequent pathogen for CAUTI. The methicillin resistance rate of S. aureus decreased from 95% in 2006 to 90.2% in 2013 (P<0.001). Amikacin resistance of Klebsiella pneumoniae and Escherichia coli gradually decreased from 43.8% in 2006 to 14.7% in 2013, and from 15.0% to 1.8%, respectively (P<0.001). Cefoxitin resistance of K. pneumoniae decreased from 47.7% in 2006 to 26.0% in 2013 (P=0.0045). Imipenem resistance of A. baumannii increased from 52.9% in 2006 to 89.8% in 2013 (P<0.001).

    Conclusion: The proportion of Gram(-) bacteria as nosocomial pathogen for CLABSI and VAP has increased. Carbapenem resistant A. baumannii emerged as the important nosocomial pathogen for DAIs in Korean ICUs.

    Jun Yong Choi, MD, PhD, Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea, Yee Gyung Kwak, MD, Inje University Ilsan Paik Hospital, Goyang, South Korea, Hyeonmi Yoo, RN, Infection Control Office, Inje University Sanggye Paik Hospital, Seoul, South Korea, Sang-Oh Lee, MD, Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, Hong Bin Kim, MD, PhD, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, Su Ha Han, RN, Soon Chun Hyang University Bucheon Hospital, Bucheon, South Korea, Hee Jung Choi, MD, Ewha Womans University, Seoul, South Korea, Hyo Youl Kim, MD, PhD, Division of Infectious Diseases, Yonsei University Wonju College of Medicine, Wonju, South Korea, Sung Ran Kim, RN, Infection Control Office, Korea University Guro Hospital, Seoul, South Korea, Tae Hyong Kim, MD, PhD, Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, South Korea, Hyukmin Lee, MD, PhD, Laboratory Medicine, Kwandong University College of Medicine, Koyang, South Korea, Hee Kyung Chun, RN, Department of Intection Control, Kyunghee University Hospital, Seoul, South Korea, Jae-Seok Kim, MD, PhD, Dept of Laboratory Medicine, Hallym University College of Medicine, Seoul, South Korea, Byung Wook Eun, MD, PhD, Department of Pediatrics, Eulji University School of Medicine, Eulji General Hospital, Seoul, South Korea, Hyun-Sook Koo, RN, Korea Centers for Disease Control & prevention, Osong, South Korea, Eun-Hee Cho, MD, Division of Epidemic Intelligence Service, Korea Centers for Disease Control and Prevention,, Cheongju, South Korea and Kyungwon Lee, MD, PhD, Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea

    Disclosures:

    J. Y. Choi, None

    Y. G. Kwak, None

    H. Yoo, None

    S. O. Lee, None

    H. B. Kim, None

    S. H. Han, None

    H. J. Choi, None

    H. Y. Kim, None

    S. R. Kim, None

    T. H. Kim, None

    H. Lee, None

    H. K. Chun, None

    J. S. Kim, None

    B. W. Eun, None

    H. S. Koo, None

    E. H. Cho, None

    K. Lee, None

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