849. Rothia mucilaginosa bacteremia: 8 year review of a single institution experience
Session: Poster Abstract Session: Bacteremia and Endocarditis
Friday, October 9, 2015
Room: Poster Hall
  • Final Rothia ID week.pdf (437.2 kB)
  • Background: Rothia spp. are gram positive bacteria which are known to cause infections in the immune compromised host. Literature is limited on the epidemiology and clinical significance of Rothiabacteremia. 

    Methods: We reviewed medical records of all patients with blood cultures positive from 2006-2014. Descriptive analysis was performed, as well as comparative analysis of neutropenic patients  (absolute neutrophil count ≤ 1000 /μL) at the time of bacteremia with non-neutropenic patients at the time of bacteremia. Fischer`s exact tests were used for comparisons of proportions and medians, respectively, with p-values <0.05 considered statistically significant.

    Results: 29 patients with Rothia bacteremia were identified. Median age was 58 years (range 27-73), with no significant gender difference (p=0.94). Charlson co-morbidity score of 4 or greater was found in 20 (69%) of patients; 20 (69%) patients had a hematologic malignancy or bone marrow transplant. While there were 15 deaths, only 1 was possibly attributed to Rothiainfection. Neutropenia was observed in 21(72%) patients at the time of bacteremia. Neutropenic patients were less likely than non-neutropenic patients to have polymicrobial infection (24% vs. 63%, p= 0.083); and were also more likely to have multiple positive blood cultures (76% vs. 0%; p value=0.0003). There was no difference between the two groups in need for ICU care, mortality or attributable mortality. Significant difference was seen for steroid use (81% vs. 13%, p=0.0014), and fluroquinolone use (86% vs.13% p=<0.0001) preceding bacteremia in neutropenic patients and this was statistically significant. Presence of intra-vascular catheter was also more pre-dominant in the neutropenic group (57% vs. 13%, p=0.035) at the time of bacteremia.

    Conclusion: Rothia bacteremia was seen in patients with medical co-morbidities, predominantly in patients with leukemia. A significant association was seen with prior use of steroids and fluroquinolone prophylaxis in neutropenic patients who developed Rothia bacteremia. Rothia bacteremia in neutropenic hosts was mostly monomicrobial and less likely thought to be a contaminant compared to non-neutropenic group.

    Maheen Abidi, MD, Infectious Disease, Medical College of Wisconsin, Milwaukee, WI, Nathan Ledeboer, PhD, D(ABMM), Microbiology, Medical College of Wisconsin, Milwaukee, WI, James Anderson, PhD, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI and Parameswaran Hari, MD, Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI


    M. Abidi, None

    N. Ledeboer, None

    J. Anderson, None

    P. Hari, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.