Methods: We retrospectively reviewed all culture-proven cases of listeriosis occurring at PUMCH between 1999 and 2014.
Results: (1) Of 69 cases, 68.1%、23.2% and 8.7% occurred among non-pregnant adults, pregnant women and neonates, respectively.(2) Clinical manifestations of 16 maternal listeriosis included fever (93.8%), leukocytosis (78.6%), chorioamnionitis (77.8%), and gastrointestinal symptoms (37.5%), fetal movement decrease or stop (31.3%). All maternal cases recovered well after the termination of pregnancy. There were 8 fetal losses, 7 neonates were complicated with listeria sepsis and were treated successfully. (3) All neonatal listeriosis were born to mothers with symptomatic listeriosis,and had disseminated sepsis with or without central nervous system (CNS) involvement. (4) Non-pregnant adult listeriosis were manifested as sepsis, CNS infection or both. 91.5% occurred among immunocompromised hosts with an underlying disease, most likely, of connective tissue diseases (CTD) or malignancy. The mortality rate was 36.2%. (5) There were 21 cases (46.7%) healthcare-associated listeriosis among non-pregnant adults infection, which involved 7 inpatient wards, however, they were non-clustered in time and ward, with an unknown origin of the infection.
Conclusion: Listeriosis is most likely underestimated in China, clinicians, especially those who provide medical care to immunocompromised hosts and pregnant women should keep a vigilance of listeria infection, and empiric antibiotic coverage of listeria should be considered when sepsis is suspected among susceptible subjects.
Y. Chen, None
T. Li, None
Y. Xu, None