Methods: We conducted a retrospective case-cohort study to investigate the effect of body mass index (BMI) on risk and severity of CDI in recently hospitalized adults with inflammatory bowel disease from 2001-2012. A model was constructed to control for known risk factors of CDI including age, antibiotic exposure, length of hospitalization and proton-pump inhibitor use.
Results: There were 68 cases of CDI in the 821 subjects included in the study. CDI occurred slightly more frequently in subjects with Ulcerative Colitis (9.5%) than those with Crohn’s disease (6.8%). Only 12% of the total population had a low BMI, but prior to controlling for known risk factors of CDI, 13.5% of the low BMI group developed CDI versus 7.5% of the normal and 7.8% of high BMI groups. Severe CDI, which occurred in 22% of the total cases, occurred more frequently in the low BMI group (38.5%) than the normal BMI (20%) or high BMI (13.3%) groups. Recurrent CDI (28% of the total cases) occurred more frequently in the higher BMI group (40%).
Conclusion: In patients with IBD, the type of bowel disease and their BMI may play a role in risk of CDI, severity of the initial infection and risk of recurrence with standard antibiotic treatment.
J. Weinberg, None
N. Bhadelia, None
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