1758. Emergence of antibiotic-nonsusceptible non-vaccine serotype pneumococci in nasopharyngeal carriage in children after the use of extended-valency pneumococcal conjugate vaccines in Korea
Session: Poster Abstract Session: Pediatric Bacterial Infections
Saturday, October 10, 2015
Room: Poster Hall
Background: This study was performed to evaluate the impact on the serotype distribution and antibiotic nonsusceptibility of pneumococcal carriage isolates from children attending daycare centers in Korea after the introduction of extended-valency pneumococcal conjugate vaccines (PCV).

Methods: Between April and June 2014, a total of 734 nasopharyngeal swabs were collected from children aged 6-83 months attending eight daycare centers located in four major cities in Korea. Collection and isolation of pneumococci was conducted in accordance with the World Health Organization Pneumococcal Carriage Working Group standards. Serotype was determined by Quellung reaction and E-test was conducted. The results were compared to previous studies.

Results: The pneumococcal carriage rate was 36.3%, non-vaccine type (NVT) was 89.2%, and the common serotypes were 23A (12.6%), 15B (10.4%), and 15C (9.5%). The proportion of NVT increased from 19.4% to 89.2% (P<0.05). The penicillin nonsusceptibility rate of NVT was 86.7%, higher compared to 75.3% in 1997-2002.

Conclusion: The introduction of extended-valency PCV has resulted in increase of NVT

In Ae Yoon, MD1, Young June Choe, MD, MPH2, Hyun Mi Kang, MD2, Jiyoung Park, MD2, Hyun Joo Jung, MD, PhD3, Chi Eun Oh, MD4, Eun Young Cho, MD5, Hyunju Lee, MD, PhD6, Hoan Jong Lee, MD, PhD2, Eun Hwa Choi, MD, PhD2 and Ki Wook Yun, MD, PhD1, (1)Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea, (2)Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea, (3)Department of Pediatrics, Ajou University School of Medicine, Suwon, South Korea, (4)Pediatrics, Kosin University Hospital, Pusan, South Korea, (5)Department of Pediatrics, Chungnam National University Hospital, Daejeon, South Korea, (6)Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea


I. A. Yoon, None

Y. J. Choe, None

H. M. Kang, None

J. Park, None

H. J. Jung, None

C. E. Oh, None

E. Y. Cho, None

H. Lee, None

H. J. Lee, None

E. H. Choi, None

K. W. Yun, None

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